Magnetic Resonance Imaging Survey of Peri-tumoral Edema of Meningioma and their Correlation with Progesterone Receptor Expression in Iranian Population

Zahra Janamiri^1, , Vahid Shahmaei¹ and Yousef Moghimi Boldaji²

¹Department of Radiology Technology, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran

²Department of Medical Physics, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran

Cite this paper:
Zahra Janamiri, Vahid Shahmaei and Yousef Moghimi Boldaji. Magnetic Resonance Imaging Survey of Peri-tumoral Edema of Meningioma and their Correlation with Progesterone Receptor Expression in Iranian Population. American Journal of Medical Case Reports. 2018; 6(5):89-91. doi: 10.12691/ajmcr-6-5-4

Abstract

Introuction: Meningiomas represent the most common primary brain tumor and comprise 3 World Health Organization (WHO) grades, the most frequent being WHO grade I (90%). In this study, we aim to investigate the prevalence and features of peri-tumoral edema of these lesions on Magnetic Resonance Imaging and their relationship with progesterone receptor (PR). Methods: From August 2011 to December 2017, we have enrolled 281 patients diagnosed with meningiomas of central nervous system, who underwent thorough imaging evaluation of diameter, size, volume and peri-tumoral edema on MRI. Of these patients, 187 patients were candidates of either surgical resection of biopsy, who were evaluated for PR by histopathological examination and immunohistochemistry (IHC) study after surgical removal. Results: Authors have found that meningiomas with higher PR positivity, represents lower volumes and also they appear as less aggressive lesions on neuroimaging. Also, we have found that meningiomas with higher PR positivity in IHC study, represents lower peri-tumoral edema on T1- and T2-weighted MRIs. On the other hand, our surgical experience showed that patients with more PR positive meningiomas, exhibit prolonged disease, with lower rate of hemorrhages. Conclusion: In this study, we have found that meningiomas with higher PR positivity, represents lower peri-tumoral edema and thus lower neurological complications; However, more advanced histopathological examination for other receptors may improve prognosis determination.

Keywords:
meningioma progesterone receptor magnetic resonance imaging histopathological examination

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