American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: https://www.sciepub.com/journal/ajmcr Editor-in-chief: Apply for this position
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American Journal of Medical Case Reports. 2016, 4(11), 354-356
DOI: 10.12691/ajmcr-4-11-1
Open AccessCase Report

Precocious Puberty Associated with an Adrenal Tumor: A Case Report

Rajkumar M. Meshram1, , Swapnil Bhongade1, Swapna Patil1, Bibhishan Jadhav1 and Payal Laddha1

1Department of Paediatrics, Government Medical College, Nagpur, Maharashtra, India

Pub. Date: November 30, 2016

Cite this paper:
Rajkumar M. Meshram, Swapnil Bhongade, Swapna Patil, Bibhishan Jadhav and Payal Laddha. Precocious Puberty Associated with an Adrenal Tumor: A Case Report. American Journal of Medical Case Reports. 2016; 4(11):354-356. doi: 10.12691/ajmcr-4-11-1

Abstract

Precocious puberty is a common complaint in pediatric medicine these days with numerous causative factors. Though adrenocortical tumors are extremely rare in children, the differential diagnosis is broad with androgen producing adrenal adenoma. Pediatric adrenocortical tumors are therapeutic and diagnostic challenges because histological criteria for distinguishing benign from malignant tumors seen in adult are not always reliable in children. Here, we report a 2 year old toddler with precocious puberty with hyperglucocortism and hypertension. His plasma testosterone, dehydroepiandrosrerone and cortisol were elevated. An abdominal MRI and CT scan identified well defined left –sided adrenal mass. Left adrenalectomy was performed and histopathological examination revealed adrenal adenoma. This case emphasizes the importance of early consideration of an adrenocortical tumor causing precocious puberty in toddler.

Keywords:
adrenal tumor adrenocortical carcinoma precocious puberty virilization

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References:

[1]  Wendt S, Shelso J, Wright K, Furmn W. Neoplastic causes of abnormal puberty. Pediatr Blood Cancer 2014;61(4):664-671.
 
[2]  Marrino S, Caruso M, Magro G, D’Amico S, La Spina M, Moscheo C, et al. Hepatoblastoma presenting as precocious puberty: a case report. J Pediatr Endocrinol Metab 2015; 28(3-4):429-32.
 
[3]  Kim MS, Yang EJ, Cho DH, Hwang PH, Lee DY. Virilizing adrenocortical carcinoma advancing to central precocious puberty after surgery. Korean J Fam Med 2015;36(3):150-153.
 
[4]  Razavi Z, RastgooHaghi A. Precocious puberty associated with an adrenal tumor: a case report. Iran J Ped Hemotol Oncol 2016;6(2):136-141.
 
[5]  Ahmed AA. Adrenocortical neoplasm in young children; age as a prognostic factor. Annals of clinical & Laboratory Science 2009;39(3):277-282.
 
[6]  Upadhye PS, Desai MP, Colaco MP, Desai PB, Deshpande RK, Mokal RA. A clinicopathological profile of adrenocortical tumors. Indian Pediatrics 1997;34(6):481-490.
 
[7]  Mittal R, Ramadan DG, Khalifa MM, Khalifa SO, Mazidi Z, Zaki M. Adrenocortical tumors in children : a Kuwait experience. Gulf J Oncolog 2012;12:38-46.
 
[8]  Sheng Q, Zhibao Lv, Weijue Xu, Jiamgbin Liu, Yibo Wu, Zhengjum Xi. A case report of adrenocortical adenoma mimicking congenital adrenal hyperplasia in a young girl. Medicine 2015;94(25):e1046.
 
[9]  Maji P, Akhouri MR, Kumar S. Viriling adrenal adenoma causing precocious puberty in a girl- a rare presentation SEAJCRR 2015;4(2):1464-1472.
 
[10]  Ribeiro RC, Michalkiewicz EL, Figueiredo BC, DeLacerdu L, Sandrini F, Pianovsky MD, et al. Adrenocortical tumors in children. Brazilian J of Medical and Biological Research 2000;33(10):1225-1234.