Corneal Manifestations of Tuberculosis: About 2 Cases

Belghmaidi Sarah^1, , Mouafik Sara Batoul², Hajji Ibtissam¹, Hocar Ouafa², Amal Said² and Moutaouakil Abdeljalil²

¹Department of Ophtalmology, University Hospital of Mohammed VI, Marrakesh, 40000, Morocco

²Department of Dermatology, University Hospital of Mohammed VI, Marrakesh, 40000, Morocco

Cite this paper:
Belghmaidi Sarah, Mouafik Sara Batoul, Hajji Ibtissam, Hocar Ouafa, Amal Said and Moutaouakil Abdeljalil. Corneal Manifestations of Tuberculosis: About 2 Cases. American Journal of Medical Case Reports. 2016; 4(5):160-164. doi: 10.12691/ajmcr-4-5-4

Abstract

Corneal tuberculosis is a rare ophthalmic manifestation of tuberculosis. The purpose of this study is to present clinical and histopathological findings in two cases of corneal tuberculosis. We reported corneal manifestation of tuberculosis in two patients including granulomatous lesion at upper third of the cornea in the first case, and sectorial interstitial keratitis in the second one. The diagnosis was based on various anamnestic, clinical, histological and evolutive arguments. An anti-tuberculosis treatment was prescribed.

Keywords:
ocular tuberculosis corneal manifestations interstitial keratitis granuloma

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References:

[1]	Golden MP, Vikram HR. Extrapulmonary tuberculosis: an overview. Am Fam Physician. 2005;72:1761-1768.
[2]	Arora R, Mehta S, Gupta D, Goyal J. Bilateral disciform keratitis as the presenting feature of extrapulmonary tuberculosis. Br J Ophthalmol 2010;94:809-810.
[3]	Gauthier AS, Delbosc B. Interstitial keratitis. EMC-Ophtalmologie. 2012; 21-215.
[4]	Zumla A, Mwaba P, Squire SB, Grange JM. The tuberculosis pandemic—which way now? J Infect 1999;38:74-9.
[5]	Sheu SJ, Shyu JS, Chen LM, Chen YY, Chirn SC, WangJS. Ophtalmology 2001;108:1580-1585.
[6]	Gupta V, shoughy S, Mahajan S, Khairallah M, Rosenbaum JT et al. Clinics of ocular tuberculosis. Ocul immunol inflamm 2015;23:14-24.
[7]	Kamal S, Kumar R, Kumar S, Goel R. Bilateral interstitial keratitis and granulomatous uveitis of tubercular origin. Eye Contact Lens 2014;40: e13-e15.
[8]	Gupta V, Gupta A, Rao NA. Intraocular tuberculosis an update. Surv ophtalmol 2007;52:561-87.
[9]	Lou SM, Montgomery PA, Larkin KL, Winthrop K, Zierhut M, Rosenbaum JT. Diagnosis and treatmen for ocular tuberculosis among uveitis specialists: the international perspective. Ocul immunol inflamm 2015; 23: 32-39.
[10]	Varma D, Anand S, Reddy AR, et al. Tuberculosis: an under-diagnosed aetiological agent in uveitis with an effective treatment. Eye (Lond) 2006;20:1068-1073.
[11]	Rosenbaum JT, Wernick R. The utility of routine screening of patients with uveitis for systemic lupus erythematosus or tuberculosis: a Bayesian analysis. Arch Ophthalmol. 1990; 108: 1291-1293.
[12]	Rao NA, Saraswathy S, Smith RE. Tuberculous uveitis: distribution of mycobacterium tuberculosis in the retinal pigment epithelium. Arch Ophthalmol. 2006;124:1777-1779.
[13]	Sakai JI, Matsuzawa S, Usui M, Yano I. New diagnostic approach for ocular tuberculosis by ELISA using the cord factor as antigen. Br J Ophthalmol. 2001;85:130-133.
[14]	Shakarchi FI. Ocular tuberculosis: current perspectives. Clin Ophtalmol. 2015;26:2223-2227.
[15]	Agrawal R, Gupta B, Gonzalez-lopez J, Rahman F, Phatak S, Triantafyllopoulou I, et al. The role of Anti tubercular therapy in patients with presumed ocular tuberculosis. Ocul immunol inflamm 2015;23:40-46.
[16]	Morimura Y, Okada AA, Kawahara S, and al. Tuberculin skin testing in uveitis patients and treatment of presumed intraocular tuberculosis in Japan. Ophthalmology 2002;109:851-857.