American Journal of Medical Case Reports
ISSN (Print): 2374-2151 ISSN (Online): 2374-216X Website: https://www.sciepub.com/journal/ajmcr Editor-in-chief: Apply for this position
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American Journal of Medical Case Reports. 2014, 2(8), 161-163
DOI: 10.12691/ajmcr-2-8-5
Open AccessCase Report

Blastoid Variant of Mantle Cell Lymphoma- a Rare Case Report

Rajeev sen1, Sumiti Gupta1, Meenu Gill1, Rachneet Kohli1, Veena Gupta1 and Renuka Verma1,

1Department of Pathology, Pt. B.D. Sharma PGIMS Rohtak, Haryana

Pub. Date: August 31, 2014

Cite this paper:
Rajeev sen, Sumiti Gupta, Meenu Gill, Rachneet Kohli, Veena Gupta and Renuka Verma. Blastoid Variant of Mantle Cell Lymphoma- a Rare Case Report. American Journal of Medical Case Reports. 2014; 2(8):161-163. doi: 10.12691/ajmcr-2-8-5

Abstract

Mantle cell lymphoma is now recognised as a rare but distinct entity in the revised WHO classification. It is now well recognised that MCL represent a broad spectrum of different histopathological subtypes. The term blastic or blastoid variant is generally used to describe cases with a homogeneous population of cells displaying lymphoblastic morphology. The blastic form of MCL may be difficult to diagnose however immunophenotyping and molecular analysis show typical mantle cell lymphoma pattern. We present a case of 30 year old male presenting with inguinal mass which was diagnosed as blastic transformation of mantle cell lymphoma based on routine histopathology and immunohistochemistry.

Keywords:
mantle cell lymphoma blastoid variant immunohistochemistry

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References:

[1]  Banks PM, Chan J, Cleary ML, Delsol G, De Wolf-Peeters G, Gatter K et al. Mantle cell lymphoma. A proposal for unification of morphologic, immunologic and molecular data. Am J Surg Pathol 1992; 16: 637-40.
 
[2]  Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC, 2008.
 
[3]  Campos E, Raffeld M, Jaffe ES. Mantle-cell lymphoma. Semin Hematol 1999; 36: 115-27.
 
[4]  Morton LM, Wang SS, Devesa SS et al. Lymphoma incidence patterns by WHO subtype in the United States, 1992-2001. Blood 2006; 107: 265-76.
 
[5]  Barista I, Romaguera JE, Cabanillas F. Mantle-cell lymphoma. Lancet Oncol 2001; 3: 141-48.
 
[6]  Gao J, Peterson L, Nelson B, Goolsby C, Chen YH. Immunophenotypic variations in mantle cell lymphoma. Am J Clin Pathol. 2009; 132 (5): 699-706.
 
[7]  Bernard M, Gressin R, Lefrere F, et al. Blastic variant of mantle cell lymphoma: a rare but highly aggressive subtype. Leukemia 2001; 15: 1785-91.