American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2024, 12(4), 58-63
DOI: 10.12691/ajmcr-12-4-1
Open AccessCase Report

Border-zone Infarct of the Corpus Callosum: A Case Report, Vascular Anatomy & Review of Literature

Nithisha Thatikonda1, , Vijaya Valaparla1, Aabishkar Bhattarai1, Chilvana Patel1 and Anand Vilaschandra Patel2

1Department of Neurology, University of Texas Medical Branch Galveston, Texas

2Department of Neurology, Baylor College of Medicine, Houston, Texas

Pub. Date: April 06, 2024

Cite this paper:
Nithisha Thatikonda, Vijaya Valaparla, Aabishkar Bhattarai, Chilvana Patel and Anand Vilaschandra Patel. Border-zone Infarct of the Corpus Callosum: A Case Report, Vascular Anatomy & Review of Literature. American Journal of Medical Case Reports. 2024; 12(4):58-63. doi: 10.12691/ajmcr-12-4-1


Corpus callosum infractions (CCI) are rare, accounting for only 3% of all ischemic strokes. CC derives its rich blood supply from anterior and posterior circulations with extensive anastomosis near the splenium tip, providing inherent protective redundancy to reduced blood flow. The presence of intracranial atherosclerotic disease (ICAD) impairs this cerebrovascular reserve, increasing susceptibility to ischemia and subsequent infarction. The border zone is more hemodynamically unstable when both circulations are affected simultaneously or in the presence of congenital anatomical variations in the cerebral vasculature. In such circumstances, accentuated hypoperfusion of the cerebral border zones secondary to systemic hypotension results in the development of border-zone infarct of the CC. We present a 47-year-old male with a midline border-zone infarct of CC due to diffuse ICAD with superimposed systemic hypoperfusion in the peri-procedural period of coronary artery bypass grafting (CABG). Due to the peculiar vascular involvement by ICAD, the infarction was isolated to CC, sparing the more common cortical border zones. Following the case report is a review discussing various anatomical locations, classifications, and pathophysiology of border-zone infarcts, with a specific focus on the vascular anatomy of the corpus callosum.

corpus callosum border zone infarct systemic hypoperfusion intracranial atherosclerotic disease

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