Lymphocyte-predominant Hodgkin’s Lymphoma: A Case Report of a Unique Large Tumor that Involving Breast and Axillary Tissue

Mehdi Seyedmoradi¹, Niloufar Mohamadian¹ and Mazaher Ramezani^{2, 3,}

¹Young Researchers and Elite Club, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran

²Molecular Pathology Research Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

³Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran

Cite this paper:
Mehdi Seyedmoradi, Niloufar Mohamadian and Mazaher Ramezani. Lymphocyte-predominant Hodgkin’s Lymphoma: A Case Report of a Unique Large Tumor that Involving Breast and Axillary Tissue. American Journal of Medical Case Reports. 2021; 9(12):690-692. doi: 10.12691/ajmcr-9-12-7

Abstract

Lymphocyte-predominant Hodgkin’s lymphoma (LPHL) that involving the breast and axillary tissue is very rare. We report a case of this subtype of Hodgkin’s lymphoma (HL) in right breast mass of a 48-year-old man, who presented with a 20 years history of this breast painless mass; but over the past year there has been an increase in the size of the mass, with pain but no discharge. Pathology report after immunohistochemistry (IHC) confirmed the LPHL.

Keywords:
Hodgkin’s lymphoma Lymphocyte-predominant Hodgkin’s lymphoma LPHL

This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

Figures

References:

[1]	Saarinen S, Pukkala E, Vahteristo P, Mäkinen MJ, Franssila K, Aaltonen LA. (2013). High familial risk in nodular lymphocyte-predominant Hodgkin lymphoma. J Clin Oncol; 31: 938-943.
[2]	Jackson C, Sirohi B, Cunningham D, Horwich A, Thomas K, Wotherspoon A (2010). Lymphocyte-predominant Hodgkin lymphoma-clinical features and treatment outcomes from a 30-year experience. Annals of Oncology; 21: 2061-2068.
[3]	Lee, A.I. & LaCasce, A.S. (2009). Nodular lymphocyte predominant Hodgkin lymphoma. The Oncologist; 14: 739-751.
[4]	Al-Mansour M, Connors JM, Gascoyne RD, Skinnider B, Savage KJ. (2010). Transformation to aggressive lymphoma in nodular lymphocyte-predominant Hodgkin’s lymphoma. J Clin Oncol; 28: 793-799.
[5]	Nogová L, Reineke T, Brillant C, Sieniawski M, Rüdiger T, Josting A, Bredenfeld H, Skripnitchenko R, Müller RP, Müller-Hermelink HK, Diehl V, Engert A. (2008). Lymphocyte-predominant and classical Hodgkin’s lymphoma: a comprehensive analysis from the German Hodgkin Study Group. J Clin Oncol; 26: 434-439.
[6]	Eichenauer DA, Engert A (2017). Nodular lymphocyte-predominant Hodgkin lymphoma: a unique disease deserving unique management. Hematology Am Soc Hematol Educ Program; 2017: 324-328.
[7]	von Wasielewski R, Werner M, Fischer R, Hansmann ML, Hubner K, Hasenclever D, Franklin J, Sextro M, Diehl V, Georgii A. (1997). Lymphocyte-predominant Hodgkin’s disease: an immunohistochemical analysis of 208 reviewed Hodgkin’s disease cases from the German Hodgkin Study Group. Am J Pathol; 150: 793-803.
[8]	Thodou E, Befani M, Triantafyllidis G, Choreftaki T, Kanellis G, Giannakoulas N. (2019). Hodgkin lymphoma mimicking inflammatory breast carcinoma: A rare case with diagnostic challenge and novel treatment. Case Reports in Hematology; 2019: Article ID 9256807.
[9]	Talwalkar SS, Miranda RN, Valbuena JR, Routbort MJ, Martin AW, Medeiros LJ. (2008). Lymphomas involving the breast: A study of 106 cases comparing localized and disseminated neoplasms. Am J Surg Pathol; 32: 1299-1309.
[10]	Mukherjee R, Mondal M, Banerjee D, Mukherjee M. (2015). Hodgkin’s lymphoma of the breast: a rare occurrence. Clin Cancer Invest J; 4(2): 282-5.
[11]	Hoimes CJ, Selbst MK, Shafi NQ, Rose MG, Rosado MF. (2010). Hodgkin's lymphoma of the breast. J Clin Oncol; 28: e11-3.
[12]	Meis JM, Butler JJ, Osborne BM. (1986). Hodgkin's disease involving the breast and chest wall. Cancer; 57: 1859-65.
[13]	Osuji CU, Ahaneku GI, Onwubuya EI, Okocha EC, Ukah C, Emegoakor CD, Omejua EG. (2013). Hodgkin’s lymphoma of the breast. J Cancer Res Ther; 9: 526-8.