American Journal of Medical Case Reports
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American Journal of Medical Case Reports. 2021, 9(10), 507-508
DOI: 10.12691/ajmcr-9-10-7
Open AccessCase Report

Fatal Case of Dysphagia Induced by Neurofibromatosis Type II

Ken-ichi Muramatsu1, Hiroki Nagasawa1, Soichiro Ota1, Kei Jitsuiki1, Hiromichi Ohsaka1 and Youichi Yanagawa1,

1Department of Acute Critical Care Medicine, Shizuoka Hospital, Juntendo University, Japan

Pub. Date: June 14, 2021

Cite this paper:
Ken-ichi Muramatsu, Hiroki Nagasawa, Soichiro Ota, Kei Jitsuiki, Hiromichi Ohsaka and Youichi Yanagawa. Fatal Case of Dysphagia Induced by Neurofibromatosis Type II. American Journal of Medical Case Reports. 2021; 9(10):507-508. doi: 10.12691/ajmcr-9-10-7


A 17-year-old boy was found in an unconscious state. He had had neurofibromatosis type 2 (NF2) since 9 years old. His history included multiple operations for NF2 at the left jugular vein foramen, thoracic spinal cord, and cervical spinal cord at 9 and 10 years old. However, remaining bilateral acoustic tumors resulted in the onset of aspirated pneumonia within a few months. He was found unconscious in his dormitory. When emergency medical technicians checked him, he was in cardiac arrest. Saburra was identified in his mouth. He did not achieve return of spontaneous circulation with advanced cardiac life support. Autopsy imaging revealed residual bilateral acoustic tumors compressing the brain stem. NF2 is a serious disease that can rapidly become life-threatening. We hope new treatments that will improve the survival of NF2 patients will be developed soon.

neurofibromatosis fatality dysphagia

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[1]  Cunha BA, Burillo A, Bouza E. Legionnaires' disease. Lancet. Blakeley JO, Plotkin SR. Therapeutic advances for the tumors associated with neurofibromatosis type 1, type 2, and schwannomatosis. Neuro Oncol. 2016 May; 18(5): 624-38.
[2]  Aboukais R, Zairi F, Bonne NX, Baroncini M, Schapira S, Vincent C, Lejeune JP. Causes of mortality in neurofibromatosis type 2. Br J Neurosurg. 2015 Feb; 29(1): 37-40.
[3]  Wu L, Deng X, Yang C, Xu Y. Spinal intradural malignant peripheral nerve sheath tumor in a child with neurofibromatosis type 2: the first reported case and literature review. Turk Neurosurg. 2014; 24(1): 135-9.
[4]  Kohda E, Hisazumi H, Hiramatsu K. Swallowing dysfunction and aspiration in neonates and infants. Acta Otolaryngol Suppl. 1994; 517: 11-6.
[5]  Akata K, Noguchi S, Kawanami T, Hata R, Naito K, Mukae H, Yatera K. Microbiology of Aspiration Pneumonia. J UOEH. 2019; 41(2): 185-192. In Japanese
[6]  Dhaenens BAE, Ferner RE, Bakker A, Nievo M, Evans DG, Wolkenstein P, Potratz C, Plotkin SR, Heimann G, Legius E, Oostenbrink R. Identifying challenges in neurofibromatosis: a modified Delphi procedure. Eur J Hum Genet. 2021 Apr 26: 1-9.