American Journal of Medical Case Reports. 2021, 9(10), 492-494
DOI: 10.12691/ajmcr-9-10-3
Open AccessCase Report
Kamyar Asadipooya1, Roohollah Narimani2, Ashraf Aminorroaya2, Bijan Iraj2, Mohammadreza Kalantarhormozi3, , Novin Afshar Moghadam4, Elaheh Kavoussi3 and Mitra Dashtizadeh3
1Division of Endocrinology and Molecular Medicine, Department of Medicine, University of Kentucky, Lexington, Kentucky
2Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
3Department of Internal Medicine, School of Medicine, Bushehr University of Medical Sciences, Bushehr, IRAN
4Department of pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IRAN
Pub. Date: June 08, 2021
Cite this paper:
Kamyar Asadipooya, Roohollah Narimani, Ashraf Aminorroaya, Bijan Iraj, Mohammadreza Kalantarhormozi, Novin Afshar Moghadam, Elaheh Kavoussi and Mitra Dashtizadeh. Cushing Syndrome Due to Pigmented Nodular Adrenal Hyperplasia in an Iranian Patient: A Case Report and Review of the Literature. American Journal of Medical Case Reports. 2021; 9(10):492-494. doi: 10.12691/ajmcr-9-10-3
Abstract
Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of Adrenocorticotropic hormone-independent Cushing syndrome. In this case, we present a case of PPNAD in 25 y/o women who presented with a 3 years history of weight gain, hirsutism, and abnormal menstruation. Our findings were suggestive of PPNAD in the pathological study of adrenal biopsy.Keywords:
Cushing syndrome PPNAD Primary pigmented nodular adrenocortical hirsutism low dose dexamethasone suppression test
This work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit
http://creativecommons.org/licenses/by/4.0/
References:
[1] | Stratakis CA, Kirschner LS, Carney JA. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. The Journal of Clinical Endocrinology & Metabolism 2001; 86: 4041-4046. |
|
[2] | Carney JA, Gordon H, Carpenter PC, Shenoy BV, Go V. The complex of myxomas, spotty pigmentation, and endocrine overactivity. Medicine 1985; 64: 270-283. |
|
[3] | Bertherat Jrm, Horvath A, Groussin L, Grabar S, Boikos S, Cazabat L, Libe R, René-Corail F, Stergiopoulos S, Bourdeau I. Mutations in regulatory subunit type 1A of cyclic adenosine 5′-monophosphate-dependent protein kinase (PRKAR1A): phenotype analysis in 353 patients and 80 different genotypes. The Journal of Clinical Endocrinology & Metabolism 2009; 94: 2085-2091. |
|
[4] | Groussin L, Horvath A, Jullian E, Boikos S, Rene-Corail F, Lefebvre H, Cephise-Velayoudom F-L, Vantyghem M-C, Chanson P, Conte-Devolx B. A PRKAR1A mutation associated with primary pigmented nodular adrenocortical disease in 12 kindreds. The Journal of Clinical Endocrinology & Metabolism 2006; 91: 1943-1949. |
|
[5] | Stratakis CA. Cushing syndrome in pediatrics. Endocrinology and Metabolism Clinics 2012; 41: 793-803. |
|
[6] | Talaei A, Aminorroaya A, Taheri D, Mahdavi KN. Carney complex presenting with a unilateral adrenocortical nodule: a case report. J Med Case Rep 2014; 8: 38. |
|
[7] | Groussin L, Cazabat L, René-Corail F, Jullian E, Bertherat J. Adrenal pathophysiology: lessons from the Carney complex. Hormone Research in Paediatrics 2005; 64: 132-139. |
|
[8] | Norhaliza M, Zanariah H, Masni M. Carney complex: Cardiac myxoma and Cushing’s syndrome. JAFES 2009; 24: 28. |
|
[9] | Ngow HA, Khairina WMNW. Primary pigmented nodular adrenocortical disease. Endokrynologia Polska 2011; 62:268-270. |
|
[10] | Siordia JA. Medical and surgical management of Carney complex. Journal of cardiac surgery 2015; 30: 560-567. |
|
[11] | Wilkes D, McDermott DA, Basson CT. Clinical phenotypes and molecular genetic mechanisms of Carney complex. The lancet oncology 2005; 6: 501-508. |
|