The Analysis of Prostaglandin E2 (PGE2), Pain Pressure Threshold (PPT), and Critical-Care Pain Observation Tools (CPOT) of Systemic Inflammatory Responses Syndrome (SIRS) Patients in Intensive Care Unit

Dwi Pantja Wibowo^1, , Suryani As’ad², Fransiscus Suhadi¹, I Wayan Suranadi³, Ilhamjaya Patellongi⁴, Irawan Yusuf⁴, Mohammad Ramli Ahmad⁵, Syafrie Kamsul Arif⁵ and Andi Husni Tanra⁵

¹Anesthesiology and Intensive Care Department, Bintaro Premier Hospital, Banten, Indonesia

²Clinical Nutrition Department, Hasanuddin University, Makassar, Indonesia

³Anesthesiology and Intensive Care Department, Udayana University, Denpasar, Indonesia

⁴Physiology Department, Hasanuddin University, Makassar, Indonesia

⁵Anesthesiology and Intensive Care Management Department, Hasanuddin University, Makassar, Indonesia

Cite this paper:
Dwi Pantja Wibowo, Suryani As’ad, Fransiscus Suhadi, I Wayan Suranadi, Ilhamjaya Patellongi, Irawan Yusuf, Mohammad Ramli Ahmad, Syafrie Kamsul Arif and Andi Husni Tanra. The Analysis of Prostaglandin E2 (PGE2), Pain Pressure Threshold (PPT), and Critical-Care Pain Observation Tools (CPOT) of Systemic Inflammatory Responses Syndrome (SIRS) Patients in Intensive Care Unit. American Journal of Medical and Biological Research. 2017; 5(2):13-17. doi: 10.12691/ajmbr-5-2-1

Abstract

Sepsis is one of the major health problems with very high costs, a number of patients who survived sepsis developed long-term complications such as persistent pain. Studies found correlation of persistent pain and PGE2 level. Aims of this study were to investigate the changes in the prostaglandin E2 levels from patients with systemic inflammatory responses syndrome (SIRS) that affect pain intensity changes with the marked increase of critical-care pain observation tools (CPOT) and decreased of the pain pressure threshold (PPT). A cross-sectional analysis to compare the values of PGE2, CPOT, and PGE2 of SIRS patients and patients without SIRS. Of the 46 patients who were the subjects of the study, there were 21 SIRS patients and 25 patients, not SIRS. Patients with SIRS had higher CPOT values and PGE2 levels than patients without SIRS; CPOT values (3.3 vs. 1.2)) and PGE2 levels (6195.81 vs. 2728.67). The PPT scores of patients with SIRS were lower than those without SIRS (4.24 vs. 7.37). The CPOT was significantly correlated (p <0.05) with PGE2 (r = -0.624). We conclude that in SIRS patients there is an increase PGE2, which in turn leads to decreased pain threshold (PPT) and increased pain score (CPOT).

Keywords:
SIRS CPOT PGE2

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