The Prevalence and Distribution of Human Onchocerciasis in Two Senatorial Districts in Ebonyi State, Nigeria

Nworie Okoro¹, Ukpabi Nkechinyere Nwali², Oli Angus Nnamdi^3, , Okonkwo Chuma Innocent⁴, Okoli Chukwudum Somadina² and Ejiofor Obiora Shedrack⁵

¹Department of Biological Sciences, Faculty of Science and Technology, Federal University Ndufu-alike, Ikwo, Ebonyi State

²Department of Applied Microbiology, Faculty of Biological Sciences, Ebonyi State University, Abakaliki, Ebonyi State, Nigeria

³Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Agulu Campus, Anambra State, Nigeria

⁴Department of Ophthalmology, Federal Teaching Hospital, Abakaliki, Ebonyi State, Nigeria

⁵Department of Pediatrics, Anambra State University Teaching Hospital, Amaku, Awka, Anambra State, Nigeria

Cite this paper:
Nworie Okoro, Ukpabi Nkechinyere Nwali, Oli Angus Nnamdi, Okonkwo Chuma Innocent, Okoli Chukwudum Somadina and Ejiofor Obiora Shedrack. The Prevalence and Distribution of Human Onchocerciasis in Two Senatorial Districts in Ebonyi State, Nigeria. American Journal of Infectious Diseases and Microbiology. 2014; 2(2):39-44. doi: 10.12691/ajidm-2-2-3

Abstract

Background: There has been a recent increase in the number of human Onchocerciasis cases in hospitals in Ebonyi Central. This study therefore sets out to determine the prevalence of the disease in Ebonyi North and Central Senatorial Zones of Ebonyi State as well as determine the age groups and sex most affected. Methods: This study was carried out in Ebonyi North and Central Senatorial Zones of Ebonyi State between January 2011 and April 2012, among subjects of 20-59 years. Diagnosis was by skin examination for onchocercal lesions, ocular examination for ocular lesion and parasitological examination for the presence of microfilariae of Onchocerca volvulus in skin biopsies and adult filariae in excised nodules. Results: Out of the 250 persons randomly examined in each zone, 82 (32.8%) persons in Ebonyi Central zone comprising of 60 (38.7%) males and 22 (23.1%) females were found positive for Onchocerca volvulus while 73 (29.2%) persons in Ebonyi North Zone comprising 48 (32.0%) males and 25 (25.0%) females. Chi-square test shows that male subjects had significantly higher diseases prevalence (p < 0.05) than their female counterparts in the two zones but combined prevalence among male and female do not differ significantly in the two zones. The age group most affected was 50-59 years with the prevalence of 40.0% in Ebonyi Central and 38.6% in Ebonyi North Zones. Out of the 155 (30.8%) persons infected in the two zones, 28 (5.6%) males and 14 (2.8%) females had Onchocercal skin lesions, 57 (11.4%) males and 22 (4.4%) females had low vision. Partial blindness was observed in 16 (3.2%) males and 8 (1.6%) females. However, 7 (1.4%) males and 3 (0.6%) females had complete blindness. Farmers were mostly affected than any other occupational group. Conclusion: The findings obtained from this work suggested that Ebonyi Central and North Senatorial Zones are Onchocerciasis hypo-endemic Zones having the prevalence rate of 32.8% and 29.2% respectively. Sex, age and occupation are related to Onchocerciasis infections in both Zones. Males are more infected than females. Massive distribution of insecticides to destroy the vector Simulium damnosum (black fly), provision of adequate antiflarial drugs - ivermectin and mass health education targeted on preventive measures are highly recommended.

Keywords:
onchocerciasis ebonyi state prevalence neglected tropical disease

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References:

[1]	Gerald, D.S and Lany, S.R. (2010) Foundations of Parasitology: McGraw-Hill, New York. Eight Editions. pp. 468-472.
[2]	Tekle, A.H., Elhassan, E., Isiyaku, S., Amazigo, U.V; Bush, S., Noma, M., Cousesns, S., Abiose, A. and Remme, J.H. Impact of long-term treatment of Onchocerciasis with Ivermectin in Kaduna State, Nigeria: First evidence of the potential for elimination in the operational area of the African programme for Onchocerciasis Control. Parasite and Vector; 2012, 5: 28-31.
[3]	Thylefors, Björn I, Négrel, A. D, Pararajasegaram Ramachandra and Dadzie, K. Y Global data on blindness. Bulletin of the World Health Organization; 1995, 73 (1): 115-121.
[4]	Pion, S.D., Kamgno, J., Demanga-Ngangue and Boussinesq, M.E. Excess Mortality associated with blindness in the Onchocerciasis focus of Mbam valley, Cameroon. Ann. Trop. Med. Parasitol; 2002, 96 (2): 181-189.
[5]	Nwoke, B.E.B. Ivermectin, the incredible Drug against Human Onchocerciasis. Medicare Journal; 1992, 5: 1-2.
[6]	World Health Organization. Status of Onchocerciasis in African Programme for Onchocerciasis Control (APOC) Countries, TDR /AFR/RP/951.6, Geneva, 2008.
[7]	World Health Organization. Onchocerciasis and its control. Report of a WHO Expert committee on Onchocerciasis control. WHO Technical Report series; 1995, 852: 1-104. Geneva.
[8]	Tielsch, J.M and Beech, A. Impact of ivermectin on illness and disability associated with Onchocerciasis. Trop. Med. Int. Health; 2004, 9 (4): 45-56
[9]	Hoerauf, A.,Buttner, D.W., Adjei, O and Pearlman, E. Onchocerciasis, B M J., 2003, 326 (7382). 207-210.
[10]	National Population Commission: Population Distribution by Sex, State, LGA & Senatorial district; Federal Republic of Nigeria, 2006 Population and Housing Census: PRIORITY TABLE, Volume III (April, 2010).
[11]	Yamane, T. Statistics: An Introductory Analysis, 2nd ed., New York: Haper and Row Press, USA. 1973, p. 45.
[12]	Cheesbrough, M. District Laboratory Practice in Tropical Countries Part 1. Cambridge University Press, New York. Second Edition. 2005, pp. 291-295.
[13]	Nwaorgu, O. C., Ohaegbulam, A., Onweluzor, I. E., Alor, E. T., Nweke, L., Agu, M. I., and Emeh, E. Results of a large scale Onchocerciasis survey in Enugu State, Nigeria. Journal of Helminthology, 1994, 68, 155-159.
[14]	Iroha, I. R., Okonkwo, C. I., Ayogu, J. E., Orji, A. E and Onwa, N. C. Epidemiology of Human Onchocerciasis among farmers in Ebonyi State, Nigeria. International Journal of Medicine and Medical Science; 2010, 2 (8): 246-250.
[15]	Akinboye, D.O., Okwong, E., Ajiteru, N; Fawole, O., Agbolade, O.M., Ayinde, O.O., Amosu, A.M., Atuloma, N.O.S., Odula, O., Owodunni, B.M., Rebecca S.N and Falade, M. Onchocerciasis among inhabitants of Ibarapa Local Government community of Oyo State, Nigeria. Biomed. Res., 2010, 21 (2): 174-178.
[16]	Akinbo, F.O and Okaka C.E. Prevalence and Socio-Economic Effects of Onchocerciasis in Ovia North East Local Government Area of Edo State, Nigeria. Rivista Parasitologic. 2005, 22 (3): 215-221.
[17]	Onwuliri, C.O.E., Nwoke, B.E.B., Lawal, I.A and Iwuala, M.O.E. Onchocerciasis in Plateau State of Nigeria. II. The prevalence among residents around the Assob River Area. Ann. Trop. Med. Parasitol; 1987, 81: 49-52.
[18]	Nwoke, B.E.B., Shiwaku, K and Takahashi, H. Nigerian Onchocerciasis: Epidemiological perceptive: J. Trop. Med. Hyg., 1991, 19 (2): 191-201.
[19]	Abanobi O. C., Edungbola L. D., Obiri G. and Nwoke B. E. B., Onchocercal Nodules: Prevalence and the Practice of Lay Nodulectomy in Mballa, Isuochi, Abia State, Nigeria. J. Nig. Opt. Assoc. 1999, 6 51-53.
[20]	Nwoke, B.E.B. The Socio-economic aspects of human Onchocerciasis in Africa: Present appraisal. J.. Hyg. Epidemiol. Microbiol Immunol; 1995, 33: 19- 28.
[21]	Somorin, A.O. “Onchocerciasis”. Int. J. Dermatol; 1983, 22: 182-281.
[22]	Anosike, J. C., Onwuliri, C. O. E. and Onwuliri, V. A. The prevalence, intensity and clinical manifestation of Onchocerca volvulus infection in two Local Government Area of Bauchi State, Nigeria; Int. J. Hyg. Envron and Health; 2001, 203 (5-6): 459-464.
[23]	Dipolu, O.O. Onchocerciasis in Benue State of Nigeria. The prevalence of the disease among the population in Manor. Int. J. Zoonosis; 1984, 10: 85-752.
[24]	Budden, F.H. Comparative Study of Ocular Onchocerciasis in Sudan –Savanna and Rainforest, Trans. Roy. Trop. Med. Hyg., 2000, 57: 64-70.
[25]	Duke, B.O.L. Strains of Onchocerca volvulus and their pathogenicity, Trop. Med. Parasitol; 1976, 22: 21-22.
[26]	Rodgers, F.C. A review of recent advances in the scientific knowledge of the symptomatology, pathology and pathogenesis of Onchocercal infections, Bulletin of World Health Organization, 1998, 27: 429-448.
[27]	Anderson, J and Fuglsang, H. Variation in numbers of microfilaria of Onchocerca volvolus in the anterior chamber of the human eye. Trans . Roy. Soc. Trop. Med Hyg., 1974, 67: 544-548.
[28]	World Health Organization. The prevention of blindness, World Health Organization Technical Report 2003, No. 518.