Determination of Antibacterial Activity of 5-Bromosalicylidene-Aniline, 5-Bromosalicylidene-4-Nitroaniline and Their Cobalt (II) Complexes

Karithi J. Muketha^1, , Gichumbi M. Joel¹, Michura J.G. Anne² and Ombaka Ochiengi¹

¹Department of Physical Sciences, Chuka University, 109-60400, Chuka, Kenya

²Department of Biological Sciences, Chuka University, 109-60400, Chuka, Kenya

Cite this paper:
Karithi J. Muketha, Gichumbi M. Joel, Michura J.G. Anne and Ombaka Ochiengi. Determination of Antibacterial Activity of 5-Bromosalicylidene-Aniline, 5-Bromosalicylidene-4-Nitroaniline and Their Cobalt (II) Complexes. American Journal of Infectious Diseases and Microbiology. 2024; 12(2):23-28. doi: 10.12691/ajidm-12-2-1

Abstract

Antibacterial resistance is a serious global health problem in human beings. Emergence and increase in number of drug resistant and multidrug resistant microorganisms is at an alarming rate. Thus, there is a pressing need for the development of novel antibacterial drugs with promising activity, which can potentially address this resistance. Schiff bases with 5-bromosalicylidene-aniline (BA), 5-bromosalicylidene-4-nitroaniline (BN) and their cobalt (II) complexes had been synthesized but there antibacterial activity has not been done. In this work, the antibacterial activity of 5-bromosalicylidene-aniline, 5-bromosalicylidene-4-nitroaniline Schiff bases ligands and their cobalt (II) complexes was investigated against two gram-positive bacteria (S aureus & L. monocytogenes) and one gram-negative bacteria (E. coli). There zones of inhibition was compared to the standard drug (gentamycin). All the test compounds displayed antibacterial potential but none of them had antibacterial activity higher than that standard. 5-bromosalicylidene-4-nitroaniline showed higher activity amongst the ligands this could be due to substitution of aniline with nitro group in its structure. Cobalt (II) complexes exhibited higher antibacterial activity in comparison to their corresponding Schiff base ligands, 5-bromosalicylidene-4-nitroaniline cobalt (II) complex showed the highest zones of inhibition amongst the all the test compounds.

Keywords:
Antibacterial activity azomethine nitrogen 5-bromosalicylaldehyde 5-bromosalicylidene-aniline 5-bromosalicylidene-4-nitroaniline

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References:

[1]	Karithi, J.M., Gichumbi, J.M., Michura J.G.A (2023). Synthesis and characterization selected of Schiff base and their cobalt (II) complexes. Global scientific journal, 11(10),413-423.
[2]	Costenaro, D., Gatti, G., Carniato, F., Paul, G., Bisio, C., & Marchese, L. (2012). The effect of synthesis gel dilution on the physico-chemical properties of acid saponite clays. Microporous and mesoporous materials, 162, 159-167.
[3]	Arulmurugan, S., Kavitha, H. P., & Venkatraman, B. R. (2010). Biological activities of Schiff base and its complexes: a review. Rasayan J Chem, 3(3), 385-410.
[4]	Nworie, F., Nwabue, F., Elom, N., & Eluu, S. (2016). Schiff bases and schiff base metal complexes: from syntheses to applications. Journal of Basic and Applied Research in Biomedicine, 2(3), 295-305.
[5]	Feng, X., Liu, F., Tan, W., Liu, X., & Hu, H. (2004). Synthesis of todorokite by refluxing process and its primary characteristics. Science in China Series D: Earth Sciences, 47, 760-768.
[6]	Lei Shi, H., Tan, S., Zhu, H. & Tan, R. (2006). Synthesis and antibacterial activities of Schiff bases Derived from 5-chloro-salicylaldehyde. European Journal of Medicinal Chemistry, 42 (20), 558-564.
[7]	Gichumbi, J.M., Omondi, B., Geraldine, L., Singh, M., Nazia, S., Chenia, H.Y. (2017). Influence of halogen substitutuion in the ligand sphere on the antitumor and antibacterial activity of half sandwich ruthenium (II) complexes [ Rux(Ƞ6arene)(C5H4N-2CH=N-Ar)]+ . Journal of inorganic and general chemistry. 0(16), 00-00.
[8]	Basha, M. T., Alghanmi, R. M., Shehata, M. R., & Abdel-Rahman, L. H. (2019). Synthesis, structural characterization, DFT calculations, biological investigation, molecular docking and DNA binding of Co (II), Ni (II) and Cu (II) nanosized Schiff base complexes bearing pyrimidine moiety. Journal of Molecular Structure, 1183, 298-312.
[9]	Claudel, M., Schwarte, J. V., & Fromm, K. M. (2020). New antimicrobial strategies based on metal complexes. Chemistry, 2(4), 849-899.
[10]	Sharma, B., Shukla, S., Rattan, R., Fatima, M., Goel, M., Bhat, M., ... & Sharma, M. (2022). Antimicrobial agents based on metal complexes: Present situation and future prospects. International Journal of Biomaterials, 2022.
[11]	Osterhoudt, K. C., & Penning, T. M. (2011). Drug toxicity and poisoning. Goodman & Gilman’s the pharmacological basis of therapeutics, 12, 73-87.