Implicated Aetiological Agents of Neonatal Urinary Tract Infection and Their Antimicrobial Sensitivity Pattern in a Tertiary Health Care Centre, Uyo, South-South Nigeria

Eno Etim Nyong¹, Enobong E. Ikpeme¹ and Sunday Babatunde Adesina^1,

¹Department of Paediatrics, University of Uyo Teaching Hospital, Uyo, Nigeria

Cite this paper:
Eno Etim Nyong, Enobong E. Ikpeme and Sunday Babatunde Adesina. Implicated Aetiological Agents of Neonatal Urinary Tract Infection and Their Antimicrobial Sensitivity Pattern in a Tertiary Health Care Centre, Uyo, South-South Nigeria. American Journal of Infectious Diseases and Microbiology. 2020; 8(3):95-98. doi: 10.12691/ajidm-8-3-2

Abstract

Background: Timely and effective antimicrobial therapy is important in the management of urinary tract infection in the new born. An accurately tailored empirical therapy, informed by periodic documentation of the aetiological agents through urine culture and antimicrobial sensitivity pattern determination is imperative in achieving this goal. This will reduce potential morbidities of delay, and ensure effective therapy before the arrival of urine culture results. The organisms causing neonatal UTI in the University of Uyo Teaching Hospital Uyo, Nigeria and their antimicrobial sensitivity pattern have not been documented in research. Objective: To determine the implicated aetiological agents of Neonatal Urinary tract infection(UTI) in the University of Uyo Teaching Hospital and their antimicrobial sensitivity pattern. Methods: A cross-sectional study on all neonates diagnosed as `suspected sepsis` who underwent sepsis evaluation between December 2013 and September 2015. Urine specimens were collected by clean catch urine collection method for culture. Results: Escherichia coli was the commonest organism isolated. Others were Klebsiella pneumonia, Morganella species and Staphylococcus aureus. Conclusions Escherichia coli was the commonest organism which was sensitive to some of the third generation Cephalosporins such as Ceftazidime and Cefotaxime.Sensitivities to Ceftriaxone, Cefuroxime and Gentamicin which initially were routine in the management of neonatal infections in the facility was comparably low.

Keywords:
neonatal neonate urinary tract infection

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References:

[1]	Thomas K. Urinary tract infections in: Rudolph CD, Rudolph AM, Hostetter MK, Lister G, Siegel NJ,(Editors) Rudolphs Paediatrics Mc-Graw Hill 2003; 1668-74.
[2]	Owa JA. Urinary tract infections. In: Azubuike JC, Nkanginieme E.O. eds. Paediatrics and Child Health in a Tropical Region, 2nd edition Owerri: African Educational Services, 2007; 30-50.
[3]	Marild S, Jodal U. Incidence rate of first-time symptomatic urinary tract infection in children under 6 years of age. Acta Pædiatr; 87(5): 549-52.
[4]	Bonadio W, Maida G. Urinary tract infections in outpatient febrile infants younger than 30 days of age. Pediatr Infect Dis J; 33(4):342-4. 2014.
[5]	Omoregie R, Igbarumah IO, Egbe CA, Ogefere CO. Urinary tract infections among neonates in Benin City. Gmbhs 4(4); 118-131.
[6]	Olusanya A, Owa JA, Olusanya OI. The Prevalence of bacteriuria among high risk neonates in Nigeria. Acta Paediatrica Scand,; 78: 94-9.
[7]	Youssef DM, Elfateh, HA, Sedeek, R Seleem S. Epidemiology of urinary tract infection in neonatal intensive care unit: A single center study in Egypt. JAMS.1:25-9. 2012.
[8]	Pineda LC, Hornik CP, Seed PC, Michael Cotton C, Laughon MM et al. Association between positive urine cultures and Necrotising Enterocolitis in a large cohort of hospitalised infants. Early Hum Dev. 91(10): 583-6.
[9]	Lin CH, Lin WC, Wang YC, Lin IC, Kao CH. Association between Neonatal Urinary Tract Infection and Risk of Childhood Allergic Rhinitis. Medicine 94(3): 1-6.
[10]	Hellström M, Jacobsson B, Jodal U, Winberg J, Odén A. Renal growth after neonatal urinary tract infection. PediatrNephrol. 1 (3); 269-75.
[11]	Sobel JD, Kaye D. Urinary tract infections. In: Mandel GL, Bennett JE, Dolin R Principles and Practice of Infectious Diseases. 7th edition. Churchill Livingstone 2010: 957-85.
[12]	Elder JS. Urinary tract infection. In: Berman RE, Kliegman RM Jenson HB. Nelson Textbook of Paediatrics 17th edition WB Saunders Company, Philadelphia. 2008: 2223-8.
[13]	Foglia EE, Lorch SA. Clinical Predictors of Urinary Tract Infection in the Neonatal Intensive Care Unit. J Neonatal Perinatal Med. 5(4): 327-333.
[14]	Airede AI. Urinary tract Infections In African Neonates. J infect 25 (1):55-62.
[15]	Mava Y, Bello M, Ambe J P, Zailani S B. Antimicrobial sensitivity pattern of organisms causing urinary tract infection in children with sickle cell anaemia in Maiduguri, Nigeria. Niger J ClinPract. 15(4):420-3.
[16]	Ibeneme CA, Oguonu T, Okafor HU, Ikefuna AN, Ozumba UC. Urinary tract infection in under five children in Enugu, South Eastern Nigeria. Niger J ClinPract. 17(5):624-8.
[17]	Pickering LK, Baker CJ, Kimberlin DW, Long SS.(eds) American academy of paediatrics, Committee on infectious disease:The red book; 29th edition, 2012.
[18]	Ballard JL, Khoury JC, Wedig K, Wang L, Ellers-Walsman BL, Lipp R. New Ballard score, expanded to include extremely premature infants. J Pediatr 119(3):417-23.
[19]	Fernandez ML, Merino NG, Garcia AT, Seoane BP, Martinez MS, Abad MT, Garcia-Pose A. A new technique for fast and safe collection of urine in newborns. Arch Dis Child 98(1):27-9.
[20]	Herreros ML, Tagarro A, Garcia-pose A, Sanche A, Carnete A, Gili P. Accuracy of a new clean-catch technique for diagnosis of urinary tract infection in infants younger than 90 days of age. Paediatr Child Health 20(6): 30-2.
[21]	Leigh DA, Williams JD. Detection of significant bacteriuria in large groups of patients. J Cli Path. 17(5): 498-3.
[22]	Vandepitte J, Verhaegen J, Engbaek K, Rohner P, Piot P, Heuck CC. Basic Laboratory Procedures in Clinical Bacteriology, 2nd ed. Geneva, World Health Organization 2003; 32-5.
[23]	Cheesebrough M. Examination of urine. In: District Laboratory practice in Tropical countries. Cambridge University press (Publ) 2002; 711-2.
[24]	Barrow GI, Feltham RKA. 2003 Cowan and Steele Manual for the identification of medical bacteria. (3rd Edition) United Kingdom, Cambridge University press 2003: 331-45.
[25]	Clinical and laboratory standard performance institute (CSLI). performance standard for antimicrobial disc susceptibility testing 22nd ed. CLSI, 950 West Valley Rd, Pennsylvania 19087 USA, 2012.
[26]	Taheri PA, Navabi B, Khatibi B. Frequency and susceptibility of bacteria causing urinary tract infection in neonates: an eight year study at neonatal division of bahrami childrens hospital Tehran, Iran. Iran j public health 42(10): 1126-11
[27]	Lee IK, Liu JW. Clinical characteristics and risk factors for mortality in Morganella morganii bacteremia. J Microbial Immunol Infect. 39(4): 328-334.
[28]	Edwards MS. Postnatal Bacterial Infections. In: Fanaroff and Martin`s Neonatal Perinatal Medicine 8th edition. Mosby 2006. Chapt 21.
[29]	Custovic A, Hadzic S. Epidemiology of bacterial intrahospital infections in newborns. Med Arh 62(5-6); 294-7.