Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens

Ahmed Mohsen¹, Alyaa Gomaa¹, Fatma Mohamed¹, Roaa Ragab¹, mennatallah Eid¹, Al-Hussein Ahmed², Areej Khalaf², Mohamed Kamal¹, Safaa Mokhtar¹, Hadeer Mohamed¹, Islam Salah¹, Rania Abbas¹, Sameh Ali³ and Rehab Mahmoud Abd El-Baky^4,

¹Undergraduate student, faculty of pharmacy, Minia University

²Undergraduate student, Faculty of science, Minia University

³Demonstrator of microbiology, Faculty of Pharmacy, Minia University

⁴Lecturer of microbiology, Faculty of Pharmacy, Minia University

Cite this paper:
Ahmed Mohsen, Alyaa Gomaa, Fatma Mohamed, Roaa Ragab, mennatallah Eid, Al-Hussein Ahmed, Areej Khalaf, Mohamed Kamal, Safaa Mokhtar, Hadeer Mohamed, Islam Salah, Rania Abbas, Sameh Ali and Rehab Mahmoud Abd El-Baky. Antibacterial, Anti-biofilm Activity of Some Non-steroidal Anti-Inflammatory Drugs and N-acetyl Cysteine against Some Biofilm Producing Uropathogens. American Journal of Epidemiology and Infectious Disease. 2015; 3(1):1-9. doi: 10.12691/ajeid-3-1-1

Abstract

Ureteral catheters are indispensable devices used in the management of ureteral obstruction. Although the stent is essential for treatment, it also has complications, which are encrustation, stone formation and biofilm formation. Biofilm infections result in a complication in the course of treatment, increasing the length of patients stay in hospital and overall cost. Catheter-associated infections are difficult to be treated with antibiotics and there is a need to change catheters due to the formation of biofilm on their surfaces. In this study, In this study, we examine the effect of some of prescribed drugs as NSAIDs and N-acetylcysteine on the adherence of S. aureus, K. pneumoniae, P. aeruginosa and Proteus mirabilis on the surface of catheters, and their effects on the preformed mature biofims. Also, we determine their antibacterial activity. The results showed that the tested agents had good antibacterial activity, a significant effect on the inhibition of adherence of the tested strains to plastic surfaces and a high disruptive effect on mature biofilms. In conclusion, the tested drugs can be used in the treatment of catheter-associated infections.

Keywords:
NSAIDs biofilm mucolytics adherence

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