Correlation of Serum Glutamate Level and IL-1β on Encephalopathy and Sepsis in Premature Infant

Fiva A Kadi^1, , Tetty Yuniati¹, Aris Primadi¹, Sjarif Hidajat¹ and Abdurachman Sukadi¹

¹Department of Child Health, Universitas Padjadjaran, Bandung, Indonesia

Cite this paper:
Fiva A Kadi, Tetty Yuniati, Aris Primadi, Sjarif Hidajat and Abdurachman Sukadi. Correlation of Serum Glutamate Level and IL-1β on Encephalopathy and Sepsis in Premature Infant. American Journal of Clinical Medicine Research. 2017; 5(3):39-42. doi: 10.12691/ajcmr-5-3-4

Abstract

Premature birth worldwide still high, in United State was 1-5% and 15.5 in 100 live birth in Indonesia. Premature babies are vulnerable to critically illness especially infections and brain injury. Major problem in brain injury are placed at white matter, in term encephalopaty of prematurity. Ischemic condition will cause glutamate excitation. In many research before have proved that there is correlation between brain and serum glutamate. Intrauterine infection in premature babies have impact to brain with the excretion of pro inflammatory cytokine such as IL-1β. Sample was obtained from 72 premature babies (under 36 weeks GA) birth in June to August 2016 in Hasan Sadikin General Hospital Bandung. This was comparative analysis with cohort approach using logistic regression analysis to determine level of glutamate and IL-1β with minimal sample 63. All premature baby which met inclusion criteria were having blood examination according to algorithm. Median glutamate serum level in premature with encephalopathy higher (67.9g/mL) than premature without encephalopathy (33.9g/mL). Median level of IL-1B serum in premature encephalopathy and sepsis (8,67g/mL) were higher than premature without encephalopathy (12.3g/mL) as well as sepsis (1.7g/mL).It was found/revealed in this study that every increase in a unit of glutamate serum level of a premature neonate means 1.04 times risk to arise encephalopathy, while the increase of IL-1 level in the first 24 hours means 1.33 times risk to arise sepsis with 95% confidence interval..

Keywords:
brain injury glutamate premature encephalopaty hypoxia

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