Correlation between Serum Ferritin Level and Growth Disorders in Children with Thalassemia

Eddy Fadlyana^1, , Fathiyah Ma’ani¹, Monalisa Elizabeth¹ and Lelani Reniarti¹

¹Department of Child Health, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, Indonesia

Cite this paper:
Eddy Fadlyana, Fathiyah Ma’ani, Monalisa Elizabeth and Lelani Reniarti. Correlation between Serum Ferritin Level and Growth Disorders in Children with Thalassemia. American Journal of Clinical Medicine Research. 2017; 5(3):31-35. doi: 10.12691/ajcmr-5-3-2

Abstract

Background Children with thalassemia receiving regular blood transfusions without optimal iron chelation may experience high levels of iron. This condition can cause oxidative stress and affect the certain organs including endocrine organs leading to growth disorders. Objective To determine the correlation between serum ferritin levels and growth disorders in children with thalassemia. Methods This was a cross sectional study conducted during April-May 2015 at Children Thalassemia Clinic, Dr. Hasan General Sadikin Hospital, Bandung. The subjects were collected using consecutive sampling. The subjects were 93 children with thalassemia aged 10–14 years divided into several groups. The study used secondary data taken from the previous studies. The data were analyzed statistically using chi-square test to determine the correlation of both variables. The correlation between serum ferritin levels and growth disorders was examined by using point-biserial correlation and logistic regression models was used to determine the correlation between age and serum ferritin levels with short stature. Results The study included 46 boys (49%) and 47 girls (51%), 62% of which had short statures. The results revealed that the mean serum ferritin level (SD) was 4.355,9 (2.149) μg/L. The correlation between serum ferritin levels and growth disorders (r=-0.260;p=0.012) by ROC value was 3542 μg/L. There was a significant correlation between age and serum ferritin levels with short stature (OR=3.248, CI95%1.304–8.086; OR=3.964, CI95%1.192–13.190). Conclusion There was significant correlation between serum ferritin levels and growth disorders.

Keywords:
thalassemia child ferritin serum growth disorder short stature

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