Sudden Death in a Person with a History of SARS-CoV-2 Infection and COVID-19 Vaccination: A Case Report

Venkataramana Kandi^1,

¹Dr. Venkataramana Kandi Ph.D., MAMS, FAGE, FRCPath (London) Department of Microbiology Prathima institute of Medical Sciences Nagunur, Karuimnagar India

Cite this paper:
Venkataramana Kandi. Sudden Death in a Person with a History of SARS-CoV-2 Infection and COVID-19 Vaccination: A Case Report. American Journal of Clinical Medicine Research. 2026; 14(1):15-18. doi: 10.12691/ajcmr-14-1-3

Abstract

With millions of people killed and billions affected worldwide, the coronavirus disease 2019 (COVID-19), which is brought on by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a disastrous situation. Through mutations, the virus is persistently propagating as different strains, sustaining its resurgence. Since vaccine development was accelerated, concerns have persisted regarding the vaccinations' efficacy and safety. Even though the COVID-19 pandemic has been contained, concerns regarding vaccines and the effects of SARS-CoV-2 infections have surfaced, casting doubt on their potential role in sudden death (SD) or sudden unnatural death (SUD). This is mostly because more and more young and middle-aged persons who were previously healthy are dying of sudden cardiac death. The scientific community should be made aware of this so that they may start investigating it and determine the causes of these changes, which will either contradict or demonstrate how SARS-CoV-2 infection, COVID-19 vaccinations, or both, contribute to SUD or SD. We report a case of SD in a person who was leading an active life until before the episode.

Keywords:
Sudden death (SD) Sudden unnatural death (SUD) COVID-19 SARS-CoV-2 vaccination pandemic

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References:

[1]	How COVID cut India's life expectancy. (2025). Accessed: August 20, 2025: https://www.rediff.com/news/report/how-covid-cut-indias-life-expectancy/20250519.htm.
[2]	26-year-old Hyderabad man's death highlights rising heart risks among youth; here's what doctors advise. (2025). Accessed: August 20, 2025: https://www.msn.com/en-in/health/health-news/26-year-old-hyderabad-man-s-death-highlights-rising-heart-risks-among-yo....
[3]	Bengal cricketer Priyajit Ghosh tragically dies at 22 during gym session. (2025). Accessed: August 20, 2025: https:// www.msn.com/en-in/sports/cricket/bengal-cricketer-priyajit-ghosh-tragically-dies-at-22-during-gym-session/ar-....
[4]	Vivek to Mayilsamy: Tamil stars who passed away recently due to a heart attack. (2025). Accessed: August 20, 2025: https://timesofindia.indiatimes.com/entertainment/tamil/movies/news/vivek-to-mayilsamy-tamil-stars-who-passed-away-re....
[5]	'Fear not, stay confident': Complete story of Power Star Puneeth Rajkumar's contributions to fight against Covid-19. https:// www.indiatoday.in/movies/regional-cinema/story/complete-story-power-star-puneeth-rajkumar-fight-against-covid....
[6]	Potluri S, Chittiprol N, Varaganti V, et al.: The Association of SARS-CoV-2 Infection and COVID-19 Vaccination With Sudden Death: An Explorative Review. Cureus. 2025, 17:89527. 10.7759/cureus.89527
[7]	List of deaths due to COVID-19. (2025). Accessed: August 20, 2025: https:// en.wikipedia.org/ wiki/ List_ of_ deaths_ due_ to_ COVID-19.
[8]	Vadakedath S, Kandi V, Mohapatra RK, et al.: Immunological aspects and gender bias during respiratory viral infections including novel Coronavirus disease-19 (COVID- 19): a scoping review. J Med Virol. 2021, 93:5295-5309. 10.1002/jmv.27081.
[9]	Kandi VR, Suvvari TK, Kutikuppala LV, et al.: Comorbidities and vaccination significantly influence on post-coronavirus disease 19 functional and health status: a single-center experience from South India. Indian J Respir Care. 2022, 11:321-326. 10.4103/ ijrc.ijrc_57_22.
[10]	Cappadona C, Rimoldi V, Paraboschi EM, Asselta R: Genetic susceptibility to severe COVID-19. Infect Genet Evol. 2023, 110:105426. 10.1016/j.meegid.2023.105426.
[11]	Samans B, Rosselló Chornet M, Rosselló Chornet A, et al.: Epigenetic immune monitoring for COVID-19 disease course prognosis. Front Immunol. 2023, 14:1107900. 10.3389/fimmu.2023.1107900.
[12]	Folegatti PM, Ewer KJ, Aley PK, et al.: Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV- 2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial. Lancet. 2020, 396:467-78. 10.1016/S0140-6736(20)31604-4.
[13]	Ahmed TI, Rishi S, Irshad S, Aggarwal J, Happa K, Mansoor S: Inactivated vaccine Covaxin/BBV152: a systematic review. Front Immunol. 2022, 13:863162. 10.3389/fimmu.2022.863162.
[14]	Hulscher N, Hodkinson R, Makis W, McCullough PA: Autopsy findings in cases of fatal COVID-19 vaccine-induced myocarditis (online ahead of print). ESC Heart Fail. 2024, 10.1002/ehf2.14680.
[15]	Basu-Ray I, Almaddah Nk, Vaqar S, Soos MP: Cardiac manifestations of coronavirus (COVID-19). StatPearls. StatPearls Publishing, Treasure Island, FL; 2024.
[16]	Cocco N, Leibundgut G, Pelliccia F, et al.: Arrhythmias after COVID-19 vaccination: have we left all stones unturned?. Int J Mol Sci. 2023, 24:10405. 10.3390/ijms241210405.
[17]	Fan H, Tang X, Song Y, Liu P, Chen Y: Influence of COVID-19 on cerebrovascular disease and its possible mechanism. Neuropsychiatr Dis Treat. 2020, 16:1359-67. 10.2147/ NDT.S251173.
[18]	Kazemi S, Pourgholaminejad A, Saberi A: Stroke associated with SARS-CoV-2 infection and its pathogenesis: a systematic review. Basic Clin Neurosci. 2021, 12:569-86. 10.32598/bcn.2021.3277.1
[19]	Paratz ED, Nehme Z, Stub D, La Gerche A: No Association Between Out-of-Hospital Cardiac Arrest and COVID-19 Vaccination. Circulation. 2023, 147:1309-1311. 10.1161/ CIRCULATIONAHA.122.063753.
[20]	Maruyama T, Uesako H: Lessons learnt from case series of out-of-hospital cardiac arrest and unexpected death after COVID-19 vaccination. Intern Med. 2023, 62:3267-3275. 10.2169/ internalmedicine.2298-23.