Cardioprotective Potentials of Aqueous Extract of Chrysophyllum Albidum (G. Don-Holl.) Pulp on Isoproterenol-Induced Cardiotoxicity in Wistar Rats

Akinlusi I. A.¹, Akinpelu B. A.², Morakinyo A. E.^1, , Adeleke A. M.¹, Oyedepo T.A.¹ and Oyedapo O.O.²

¹Department of Biochemistry, Adeleke University, Ede, Osun State

²Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile-Ife, Osun State

Cite this paper:
Akinlusi I. A., Akinpelu B. A., Morakinyo A. E., Adeleke A. M., Oyedepo T.A. and Oyedapo O.O.. Cardioprotective Potentials of Aqueous Extract of Chrysophyllum Albidum (G. Don-Holl.) Pulp on Isoproterenol-Induced Cardiotoxicity in Wistar Rats. American Journal of Cardiovascular Disease Research. 2019; 6(1):15-22. doi: 10.12691/ajcdr-6-1-3

Abstract

Cardiovascular diseases are the number one cause of death globally. A number of medicinal plants have shown their beneficial effect on cardiovascular system. The study investigated the cardioprotective potential of aqueous C. albidium pulp extract on isoproterenol-induced cardiotoxicity. The extract of C. albidum was screened for the presence of phytochemicals and the concentrations of phenolics and total flavonoids were also evaluated. Male wistar rats (30) were equally grouped into five. Group 1 rats received normal saline only, Group 2 rats received normal saline and induced with ISO, Group 3 rats were orally pretreated with propanolol and induced with ISO while Group 4 and 5 rats were orally pretreated with 100mg/kg bwt and 200mg/kg bwt C. albidum pulp respectively and induced with ISO. The activities of CK-MB, LDH, ALT, AST and the concentrations of lipid profile were estimated in the blood plasma of the experimental rats. Data was analyzed using appropriate descriptive and inferential statistics. The findings of the study revealed the presence of phytochemicals such as alkaloids, tannins, flavonoids, cardiac glycosides. There was a significant decrease in the activities of CK-MB, LDH, ALT and AST in the plasma of the pretreated C. albidum pulp extract groups. Pretreatment with the C. albidum pulp extract at 100mg/kg bwt and 200mg/kg bwt caused significant alterations in the lipid profile of the animals. The result of this study suggested that aqueous C. albidum pulp extract may serve as a potential cardioprotective agent against cardiovascular diseases.

Keywords:
cardiotoxicity ISO (Isoproterenol) chrysophyllum albidum antioxidants

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