Synthesis And Biological Activity of Some New 1,3,4-Oxadiazole Derivatives

Chhater Singh^1, , Reeta Karal² and Bijander Kumar¹

¹Mahaveer College of Pharmacy, Meerut

²OPJS University, Rajasthan

Cite this paper:
Chhater Singh, Reeta Karal and Bijander Kumar. Synthesis And Biological Activity of Some New 1,3,4-Oxadiazole Derivatives. American Journal of Biomedical Research. 2018; 6(1):25-32. doi: 10.12691/ajbr-6-1-4

Abstract

Oxadiazole a heterocyclic nucleus has attracted a wide attention of the chemists in search for new therapeutic molecules. Compounds having a five membered ring containing one oxygen and two nitrogen atoms are called oxadiazoles or in older furadiazoles. Oxadiazole is considered to be derived from furan by replacement of two methane groups by two pyridine type nitrogen called as furadiazoles. The structures of the newly synthesized derivatives were established by the combined practice of UV, IR, 1H NMR, and 13C NMR. Further these synthesized derivatives were subjected to anticonvulsant, neurotoxicity, antibacterial and antifungal activity against all the selected microbial and antifungal strains in comparison with ofloxacin (antibacterial), Fluconazole (antifungal), Anticonvulsant and Neurotoxicity with Phentoin and Phenobarbital. The antibacterial activity of synthesized derivatives was correlated with their physicochemical and structural properties by QSAR analysis.

Keywords:
oxadiazole derivatives heterocyclic nucleus furadiazoles antibacterial and antifungal activity

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