American Journal of Biomedical Research
ISSN (Print): 2328-3947 ISSN (Online): 2328-3955 Website: Editor-in-chief: Hari K. Koul
Open Access
Journal Browser
American Journal of Biomedical Research. 2018, 6(1), 25-32
DOI: 10.12691/ajbr-6-1-4
Open AccessArticle

Synthesis And Biological Activity of Some New 1,3,4-Oxadiazole Derivatives

Chhater Singh1, , Reeta Karal2 and Bijander Kumar1

1Mahaveer College of Pharmacy, Meerut

2OPJS University, Rajasthan

Pub. Date: June 12, 2018

Cite this paper:
Chhater Singh, Reeta Karal and Bijander Kumar. Synthesis And Biological Activity of Some New 1,3,4-Oxadiazole Derivatives. American Journal of Biomedical Research. 2018; 6(1):25-32. doi: 10.12691/ajbr-6-1-4


Oxadiazole a heterocyclic nucleus has attracted a wide attention of the chemists in search for new therapeutic molecules. Compounds having a five membered ring containing one oxygen and two nitrogen atoms are called oxadiazoles or in older furadiazoles. Oxadiazole is considered to be derived from furan by replacement of two methane groups by two pyridine type nitrogen called as furadiazoles. The structures of the newly synthesized derivatives were established by the combined practice of UV, IR, 1H NMR, and 13C NMR. Further these synthesized derivatives were subjected to anticonvulsant, neurotoxicity, antibacterial and antifungal activity against all the selected microbial and antifungal strains in comparison with ofloxacin (antibacterial), Fluconazole (antifungal), Anticonvulsant and Neurotoxicity with Phentoin and Phenobarbital. The antibacterial activity of synthesized derivatives was correlated with their physicochemical and structural properties by QSAR analysis.

oxadiazole derivatives heterocyclic nucleus furadiazoles antibacterial and antifungal activity

Creative CommonsThis work is licensed under a Creative Commons Attribution 4.0 International License. To view a copy of this license, visit


Figure of 17


[1]  P. Sengupta, M. Mal, S. Mandal, J. Singh, and T. K. Maity, “Evaluation of antibacterial and antifungal activity of some 1, 3, 4 oxadiazoles,” Iranian Journal of Pharmacology and Therapeutics, vol. 7, no. 2, pp. 165-167, 2008.
[2]  N. Bhardwaj, S. K. Saraf, P. Sharma, and P. Kumar, “Syntheses, evaluation and characterization of some 1, 3, 4-oxadiazoles as antimicrobial agents,” E-Journal of Chemistry, vol. 6, no. 4, pp.1133-1138, 2009.
[3]  Hui, X. P.; Chang-Hu, C.; Zhang, Z. Y., Ind. J. Chem., 2000, 41(B), 2176-2179.
[4]  Mulichen, N. D.; Wilson, M. W.; Connor, D. T., J. Med. Chem., 1993, 1090-1099.
[5]  Garudachari, B.; Isloor, A.M.; Satyanaraya, M.; Ananda, K.; Fun, H-K. Synthesis, characterization and antimicrobial studies of some new trifluoromethyl quinoline-3-carbohydrazide and 1, 3, 4-oxadiazoles. RSC Adv,- 2014, 4(58), 30864-30875.
[6]  Chandrakantha, B.; Shetty, P.; Nambiyar, V.; Isloor, N.; Isloor, A.M. Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety. Eur. J. Med. Chem., 2010, 45(3), 1206-1210.
[7]  Rane, R.A.; Bangalore, P.; Borhade, S.D.; Khandare, P.K. Synthesis and evaluation of novel 4-nitropyrrole-based 1,3,4-oxadiazole derivatives as antimicrobial and anti-tubercular agents. Eur. J. Med. Chem., 2013, 70, 49-58.
[8]  Khalilullah, H.; Khan, S.; Nomani, M.S.; Ahmed, B. Synthesis, characterization and antimicrobial activity of benzodioxane ring containing 1, 3, 4-oxadiazole derivatives. Arabian. J. Chem., 2016, 9(2), 1029-1035.
[9]  Masciocchi, D.; Villa, S.; Meneghetti, F.; Pedretti, A.; Barlocco, D.; Legnani, L.; Toma, L.; Kwon, B.M.; Nakano, S.; Asai, A. Biological and computational evaluation of an oxadiazole derivative (MD77) as a new lead for direct STAT3 inhibitors. MedChemComm, 2012, 3, 592-599.
[10]  Shin, D.S.; Masciocchi, D.; Gelain, A.; Villa, S.; Barlocco, D.; Meneghetti, F.; Pedretti, A.; Han, Y.M.; Han, D.C.; Kwon, B.M. Synthesis, modeling, and crystallographic study of 3, 4-disubstituted-1, 2, 5-oxadiazoles and evaluation of their ability to decrease STAT3 activity. MedChemComm, 2010, 1, 156-164.
[11]  Desai, N.; Dodiya, A.M.; Rajpara, K.M.; Rupala, Y.M. Synthesis and antimicrobial screening of 1, 3, 4-oxadiazole and clubbed thiophene derivatives. J. Saudi Chem. Soc., 2014, 18(3), 255-261.
[12]  Karthikeyan, M.S.; Prasad, D.J.; Mahalinga, M.; Holla, B.S.; Kumari, N.S. Antimicrobial studies of 2,4-dichloro-5-fluorophenyl containing oxadiazoles. Eur. J. Med. Chem., 2008, 43(1), 25-31.
[13]  R. Fra´nski, “Biological activities of the compounds bearing 1,3,4-oxa(thia)diazole ring,” Asian Journal of Chemistry, vol. 17, no. 4, pp. 2063-2075, 2005.
[14]  J. Parekh and S.Chanda, “In vitro antimicrobial activity of Trapa natans L. fruit rind extracted in different solvents,” African Journal of Biotechnology, vol. 6, no. 6, pp. 766–770, 2007.
[15]  X. Yao, M. Jericho, D. Pink, and T. Beveridge, “Thickness and elasticity of gram-negative murein sacculi measured by atomic force microscopy,” Journal of Bacteriology, vol. 181, no. 22, pp. 6865-6875, 1999.