Review on Migraine: Pathophysiology and Treatment

Singh Chhater^1, , Reeta Karal² and Bijander Kumar¹

¹Mahaveer College of Pharmacy, Meerut, (U.P.)

²OPJS University, Churu, Rajasthan

Cite this paper:
Singh Chhater, Reeta Karal and Bijander Kumar. Review on Migraine: Pathophysiology and Treatment. American Journal of Biomedical Research. 2018; 6(1):20-24. doi: 10.12691/ajbr-6-1-3

Abstract

Management of migraine headaches should begin with identification and removal, if possible, of factors that consistently provoke migraine attacks. Some of these triggers may include environmental factors such as cigarette smoke, loud noise, and bright or flickering lights; psychological factor including stress, anxiety. A number of medications have been associated with drug-intended migraine. Some of these are cimetidine, cocaine, ethnyl estradiol, fluoxitine, histamine, and hormone replacement therapy. Aspirin is considered the drug of choice in these people. In present time treatment involves the natural therapy, which includes feverfew, turmeric, kava, evening primrose and gymnema. Other herbal remedies are shatavari, brahmi, jatamansi, musta. Acupuncture, Homeopathy, Spinal manipulation also include in natural therapy. This Review provides an up-to-date overview of the classification of migraine, basic mechanisms and risk factors of migraine, and the currently established treatment options.

Keywords:
migraine ayurveda herbal acupuncture and aromatherapy

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References:

[1]	Gupta K. Vine, Migraine-related vertigo: The challenge of the basic sciences, Clinical Neurology and Neurosurgery. 2005; 108 (1), 109-110.
[2]	Bousser M.G. and Welch K.M., Relation between migraine and stroke: American Journal of Ophthalmology. 2005; 140 (6), 1173.
[3]	Tripathi K.D., Essential of medical pharmacology, 6th Edition: Jaypee Brothers Medical Publishers (P) LTD; 2008
[4]	Roger K. Cady, Diagnosis and treatment of migraine: clinical cornerstone.1999; 1(6), 21.
[5]	Tepper S., Dahlöf C., Dowson A., Newman L., Mansbach H., Jones M., et al. (2004) Prevalence and diagnosis of migraine in patients consulting their physician with a complaint of headache: data from the Landmark Study. Headache 44: 856-864.
[6]	Weatherall M. (2006) Acute neurology in a twenty-first century district general hospital. J R Coll Physicians Edinb 36: 196-200.
[7]	Stone J., Carson A., Duncan R., Roberts R., Warlow C., Hibberd C., et al. (2010) Who is referred to neurology clinics? – The diagnoses made in 3781 new patients. Clin Neurol Neurosurg 112: 747-751.
[8]	Natoli J., Manack A., Dean B., Butler Q., Turkel C., Stovner L., et al. (2010) Global prevalence of chronic migraine: a systematic review. Cephalalgia 30: 599-609.
[9]	Facchinetti F, Sances G, Borella P, Genazzani AR, Nappi G., Magnesium prophylaxis of menstrual migraine: effects on intracellular Magnesium”: Headache. 1991; 31(5), 298-301.
[10]	Buse D., Manack A., Serrano D., Reed M., Varon S., Turkel C., et al. (2012). Headache impact of episodic and chronic migraine: results from the American Migraine Prevalence and Prevention study. Headache52: 3-17.
[11]	World Health Organization (2012) WHO Global Health Estimates: DALYs, 2000–2012. Available at: http://www.who.int/healthinfo/global_burden_disease/en/ (accessed January 2015).
[12]	Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders, 2nd ed. Cephalalgia. 2004; 24(Suppl 1): 9-160.
[13]	Stewart WF, Shechter A, Rasmussen BK. Migraine prevalence. A review of population-based studies. Neurology. 1994;44(6 Suppl 4): S17-S23.
[14]	Hu XH, Markson LE, Lipton RB, Stewart WF, Berger ML. Burden of migraine in the United States: disability and economic costs. Arch Intern Med. 1999; 159(8):813-818.
[15]	Lipton RB, Bigal ME, Diamond M, Freitag F, Reed ML, Stewart WF. Migraine prevalence, disease burden, and the need for preventive therapy. Neurology. 2007; 68(5):343-349.
[16]	Olesen J, Bousser MG, Diener HC, et al. Headache Classification Committee. New appendix criteria open for a broader concept of chronic migraine. Cephalalgia. 2006; 26(6): 742-746.
[17]	Gursoy-Ozdemir Y, Qiu J, Matsuoka N, et al. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest. 2004; 113(10): 1447-1455.
[18]	Leao AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol. 1944; 7: 359-390.
[19]	Busija DW, Bari F, Domoki F, Horiguchi T, Shimizu K. Mechanisms involved in the cerebrovascular dilator effects of cortical spreading depression. Prog Neurobiol. 2008; 86(4): 379-395.
[20]	Burstein R, Collins B, Jakubowski M. Defeating migraine pain with triptans: a race against the development of cutaneous allodynia. Ann Neurol. 2004; 55(1): 19-26.
[21]	Reynales H., Aycardi E., Valencia D., Migraine: implications for work, disability and request for health services in Colombia: Rev Neurol. Jun 2001; 32(11), 1001-5.
[22]	Health Encyclopedia - Diseases and Conditions, www.healthscout.com/ency/68/21/main.html.
[23]	Marina de Tommaso, Central n ervous system ex citability in migraine: Pain. 2005; 118 (1- 2), 1-2.
[24]	Natural Migraine Treatment FAQ; www.migrainepage.com/faqs/natural
[25]	Minet M., Radat F., Chautard M. and Lucas C., “Anxiety and depression associated with migraine: Influence on migraine subjects' disability and, quality of life, and acute migraine management”: pain. 2005; 118 (3), 319-326.
[26]	Pearce Alison, A paediatrician's guide to complementary medicine: Current pediatrics.
[27]	Hopwood V. and Lewith G., Acupuncture trials and methodological considerations: Clinical Acupuncture and Oriental Medicine. 2002; 3 (4); 192-199.
[28]	Richardson P. M. and Vincent C. A., “Acupuncture for the treatment of pain: A Review of evaluative research”: Pain. 1986; 24 (1); 15-40.
[29]	Brown. J. M., Imagery coping strategies in the treatment of migraine: Pain. 1984; 18(2), 157-67.
[30]	Migraine Treatment FAQ; www.faqs.org/faqs/medicine/migraine/natural -cures.
[31]	Wu C., Chen F. , Wang X., Kim H., He G., and Huang G., Antioxidant constituents in feverfew (Tanacetum parthenium) extract and their chromatographic quantification: Food Chemistry. 2006; 96 (2), 220-227.
[32]	Volz H.P., et al., kava- kava Extract WS 1490 versus placebo in anxiety Disorders – A Randomized Placebo-controlled 25 week Outpatient trail: Pharmacopsychiatry. 1997; 30 (1), 1-5.
[33]	Singh Y. N., “Kava: An overview”: J Ethnopharmacol. 1992; 37 (1), 13-45.
[34]	Ammon H.P. et al., Pharmacology of Curcuma longa: Planta Med. 1991; 57 (1), 1-7.
[35]	Sreejayyan, Rao M.N., Nitric oxide scavenging by curcuminoids: J Pharm Pharmacol. 1997; 49 (1), 105-7.
[36]	Deodhar SD, et al., Preliminary Studies on Anti-Rheumatic Activity of Curcumin: Ind J Med Res., 1980; 71, 632.
[37]	Snow J.M., Curcuma longa L. (Zingiberaceae): Protocol Journal of Botanical Medicine. 1995; 1 (2), 43-46.
[38]	Chapkin RS, et al., Dietry Influences of Evening Primrose and fish Oil on the Skin of Essential Fatty Acid-deficient Guinea Pigs: J Nutr. 1987; 117 (8), 1360-70.
[39]	Dutta-Roy AK, et al., Effects of Linoelic and Gamma-linoleic Acid (Efamol Evening Primerose Oil) on Fatty Acid-binding Proteins of rat liver: Mol Cell Biochem., 1990; 98 (1-2), 177-82.
[40]	Warshaw E.M., Zug K.A., Sesquiterpene lactone allergy: American Journal of Contact Dermatitis. 1996; l 7 (1), 1-23
[41]	Tea, history, research, tradition origin, camellia, sinensis high tea low tea, teas, Stash; www.stashtea.com/ydwwtea
[42]	Groenewegen W.A., Heptinstall S., Amounts of feverfew in commercial preparations of the herb: The Lancet. 1986; 1 (8471), 44-45.
[43]	Ramadan N.M. et al., Low Brain Magnesium in Migraine: Headache. 1989; 29 (9 ), 590-93.
[44]	Weaver K., Magnesium and its Role in Vascular Reactivity and Coagulation: Contemp Nutr. 1987; 12 (3), 1.
[45]	Facchinetti F. et al, “Magnesium Prophylaxis of menstrual migraine: effect on intra cellular.
[46]	Schoenen J, et al., “Effectiveness of highdose Riboflavin in migraine prophylaxis: A Randomized con trolled trail”: Neurology. 1998; 50 (2), 466-70.
[47]	Thysjjacobs S., Alleviation of Migraine with therapeutic Vitamin D and Calcium: Headache. 1994; 34 (10), 590-2.
[48]	Thysjjacobs S., Vitamin D and Calcium in menstrual migraine: Headache.1994; 34 (9).
[49]	Wagner W. et al., Prophylactic treatment of migraine with gamma-linolenic and alphalinolenic acids: Cephalagia.1997; 17 (2), 127-30.
[50]	NHS Direct Online Health Encyclopaedia Migraine, www.nhsdirect.nhs.uk.
[51]	Crevits L., Bosman T., Migraine-related vertigo, the challenge of the basic sciences: Clinical Neurology and Neurosurgery. 2005; 108 (1), 111-112.