Potential Investigation of Anti-Inflammatory Activity and Phytochemical Investigations of Ethanolic Extract of Glycosmis Pentaphylla Leaves

Prawej Ansari¹, Shofiul Azam², Md. Reyad-ul-ferdous^{1, 3,} , Apsana Hossain¹, Tasana Azad¹, Sukdeb Goswami¹ and Kallol Kanti Mondal¹

¹Department of Pharmacy, North South University, Dhaka-1229, Bangladesh

²Department of Pharmacy, International Islamic University Chittagong, 154/A, College Road, Chittagong-4203, Bangladesh

³Department of Pharmacy, Progati Medical Institute, Dhaka-1216, Bangladesh

Cite this paper:
Prawej Ansari, Shofiul Azam, Md. Reyad-ul-ferdous, Apsana Hossain, Tasana Azad, Sukdeb Goswami and Kallol Kanti Mondal. Potential Investigation of Anti-Inflammatory Activity and Phytochemical Investigations of Ethanolic Extract of Glycosmis Pentaphylla Leaves. American Journal of Biomedical Research. 2015; 3(1):6-8. doi: 10.12691/ajbr-3-1-2

Abstract

The present study is carried out with the ethanolic extract of leaves of Glycosmis pentaphylla. Traditional use of it inspired us to investigate the blood corpuscular protective power of this plant as it used as blood tonic in Chinese traditional medicine. By the phytochemical screening we have both flavonoids and steroids. There’s also alkaloids are found which have extensive physiologic action embodying analgesic activity. This investigation is made following the most simple, reliable and less time consuming method. As the human red blood corpuscular membrane is similar to lysosomal membranes that influence inflammatory process. Significant result obtained using ethanolic extract of G. pentaphylla have better acceptance as it shows good response in inhibiting hemolysis (55.16%) at highest concentration and these investigation surely stimulate further screening and isolation process.

Keywords:
G. pentaphylla lysosome membrane stability phytochemicals investigation

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References:

[1]	Ghani A. Medicinal Plants of Bangladesh. 2nd ed. The Asiatic Society of Bangladesh, 2003: 1-17.
[2]	A review on the pharmacology and phytochemistry of traditional medicinal plant, Glycosmis pentaphylla (Retz.) Correa, Sreejith, P. S.; Praseeja, R. J.; Asha, V. V., Journal of Pharmacy Research, 2012; 5 (5), p 27-23.
[3]	Antidiabetic and Analgesic Effects of Glycosmis pentaphylla (Retz.) in Swiss Albino Mice,Most. Chand Sultana Khatun, M Ripon Mia, M Ashraf Ali, M Moshiur Rahman, Khadiza Begum, Kohinur Begum, Ibrahim medical college journal, 2012; 6 (1), p 21-26.
[4]	Pharmacological studies on Glycosmis pentaphylla (corr.) whole plant, Kishore Kumar Sarkar, Md. Lokman Hossain, Arif Hossin, Himangsu Mondal, A.S.M. Monjur-Al- Hossain, Md. Iqbal Ahmed, Samir Kumar Sadhu, pharmacology online, 2013; 1, p: 230-236.
[5]	The apoptosis inducing effect of Glycosmis pentaphylla (Retz.) Correa and its influence on gene expression in hepatocellular carcinoma cell line, Hep3 B, Sreejith PS, Mascarenhas RR, Praseeja RJ, Asha VV, J Ethnopharmacol, 2012; 139 (2): 359-65.
[6]	Handa SS, Khanuja SPS, Longo G, Rakesh DD; Extraction technologies for medicinal and aromatic plant. International centre for science and high technology, 2008.
[7]	Ghani A;1998; Medicinal plants of Bangladesh: Chemical constituents and uses. Asiatic society of Bangladesh, Dhaka.
[8]	Reyad-ul-Ferdous M, Alam TT, Islam MA, Khan MZI, Tasnim F, et al. Ex-Vivo Cardioprotective and Cytotoxic Screening of Fruits of Parmentiera ereifera Seem. Biol Med 2014; 6: 219.
[9]	Md. Reyad-ul-ferdous, Md. Asif Hassan, Nawfel Abdullah, Mridul sarker, Faizul Hafiz and Tasnim Iffat. Preliminary in Vitro Phytochemical Screenings of the Barks of Parmentiera cereifera Seem .International Journal of Innovative and Applied Research, 2014; 2 (7): 57-60.
[10]	Sofowora A; 1903; Medicinal plant and traditional medicine in Africa; 2nd ed.; Nigeria Spectrun Books Ltd.; Screening plants for Bioactive agent; pp. 134-156.
[11]	Siddiqui AA and Ali M; (1997); Practical Pharmaceutical Chemistry; 1st ed.; CBS Publishers and Distributors, New Delhi, pp: 126-131.
[12]	Evans WC; Trease and Evans pharmacognosy; London: WB Saunders; 2002.
[13]	Varadarasu M, Mounisamy S, Kavimani V, Balu S, Quine D; Evaluation of anti-inflammatory and membrane stabilizing properties of ethanol extract of Cansjerarheedii J. Gmelin (Opiliaceae). Journal of Pharmacology and Therapeutics. 2007; pp: 235-237.
[14]	James O, Nnacheta OP, Wara HS, Aliyu UR; Invitro and in vivo studies on the anti oxidative activities, membrane stabilization and Cytotoxicity of water spinach from ipogi ponds (Nigeria). Int J of Pharm tech Research. 1 (3), 474-482.
[15]	Md. Reyad-Ul-Ferdous, Sayma Akhter, Md. Zahirul Islam Khan, Md. Eshak Khan, Md. Atiqul Islam, Md. Sharif Ullah. Ex-Vivo Anti-Inflammatory and Antimicrobial Activities of the Leaves of Bauhinia acuminata. American Journal of Life Sciences. 2014; 2 (5), pp. 267-270.
[16]	Kam PCA and Liew S; Traditional Chinese herbal medicine and anaesthesia. Anaesthesia. 2002; 57: 1083-1089.
[17]	Othman RA, Moghadasian MH; Beyond cholesterol-lowering effects of plant sterols: clinical and experimental evidence of anti-inflammatory properties. International Life Sciences Institute. 2011; 69 (7): 371-82.