Dyslipidemia and High Adiposity are Risk Factors for Osteoarthritis in Adults in Nigeria

Razaq Abiodun Ogunbona¹, Bose Etaniamhe Orimadegun^1, , Samuel Olusegun Ogunlade², Adesoji A. Fasanmade³ and Emmanuel Oluyemi Agbedana¹

¹Department of Chemical Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria

²Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria

³Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria

Cite this paper:
Razaq Abiodun Ogunbona, Bose Etaniamhe Orimadegun, Samuel Olusegun Ogunlade, Adesoji A. Fasanmade and Emmanuel Oluyemi Agbedana. Dyslipidemia and High Adiposity are Risk Factors for Osteoarthritis in Adults in Nigeria. American Journal of Biomedical Research. 2020; 8(1):19-24. doi: 10.12691/ajbr-8-1-4

Abstract

Clinical anecdotal evidence suggests that the risk of cardiovascular disease among adult Nigerians with osteoarthritis (OA) exist, but evidence from analytical research remains scarce in the literature. Therefore, this research was conducted to examine the relationship between OA and certain risk factors for cardiovascular disease in adults in Nigeria. We identified 40 consecutive cases of OA, age- and sex-matched adults who had no symptoms or signs suggestive of OA as controls at the medical outpatient clinics of two tertiary hospitals in Ibadan, Nigeria. Plasma lipids and glucose, as well as serum homocysteine, were determined following standard procedures. Other indices of cardiovascular risk factors included body mass index, waist and hip circumference, and body adiposity index. The associations between OA and the factors were explored using logistic regression analysis at p = 0.05. Participants’ ages ranged from 31 to 74 years. There were four males and 36 females in cases and controls, respectively. The odds of low high-density lipoprotein cholesterol (OR=6.71; 95% CI: 4.58, 10.31), high low-density lipoprotein (OR=5.68; 95% CI: 3.74, 11.42), high body adiposity index (OR=1.27; 95% CI: 1.11, 1.46) and high total cholesterol-to-high-density lipoprotein ratio (OR=0.02; 95% CI: 0.01, 0.51) were higher in individuals with OA than controls. Dyslipidaemia and increased adiposity are important risk factors for osteoarthritis in adults in Nigeria. These factors could be useful for routine screening and stratification of cardiovascular risk in susceptible individuals.

Keywords:
dyslipidaemia excess body fatness dyslipoproteinemia hypercholesterolemia osteoarthritis

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References:

[1]	Woolf AD, Pfleger B. Burden of major musculoskeletal conditions. Bull World Health Organ. 2003; 81: 646-56.
[2]	McDonough CM, Jette AM. The contribution of osteoarthritis to functional limitations and disability. Clin Geriatr Med. 2010; 26: 387-99.
[3]	Johnson VL, Hunter DJ. The epidemiology of osteoarthritis. Best Pract Res Clin Rheumatol. 2014; 28: 5-15.
[4]	Allen KD, Golightly YM. Epidemiology of osteoarthritis: state of the evidence. Curr Opin Rheumatol. 2015; 27: 276.
[5]	WHO. Chronic rheumatic conditions. Chronic diseases and health promotion. Geneva: World Health Organization; 2000.
[6]	United Nation. WORLD POPULATION TO 2300 New York: Department of Economic and Social Affairs, Population Division, United Nation; 2004.
[7]	Maetzel A, Li LC, Pencharz J, Tomlinson G, Bombardier C, Community H, Arthritis Project Study T. The economic burden associated with osteoarthritis, rheumatoid arthritis, and hypertension: a comparative study. Ann Rheum Dis. 2004; 63: 395-401.
[8]	Yoshimura N, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T. Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study. Osteoarthritis Cartilage. 2012; 20: 1217-26.
[9]	Kluzek S, Newton JL, Arden NK. Is osteoarthritis a metabolic disorder? British Medical Bulletin. 2015; 115: 111-21.
[10]	Fernandes GS, Valdes AM. Cardiovascular disease and osteoarthritis: common pathways and patient outcomes. Eur J Clin Invest. 2015; 45: 405-14.
[11]	Gandhi R, Razak F, Tso P, Davey JR, Mahomed NN. Asian ethnicity and the prevalence of metabolic syndrome in the osteoarthritic total knee arthroplasty population. J Arthroplasty. 2010; 25: 416-9.
[12]	Ogbu V, Enweani U, Madu K, Iyidobi E. Prevalence and pattern of osteoarthritis of the knee at National Orthopaedic Hospital Enugu. Niger J Med. 2016; 25: 336-40.
[13]	Ibrahim D, Borodo M, Adelowo O. Clinical pattern of knee osteoarthritis in patients seen at rheumatology clinic of Aminu Kano Teaching Hospital, Northwestern Nigeria. Afr J Rheumatol 2014; 2: 13-7.
[14]	Yerima A, Adelowo O, Mustapha S. Prevalence and pattern of knee osteoarthritis in patients presenting at a rheumatology clinic of a tertiary hospital in north east Nigeria. Afr J Rheumatol. 2018; 6: 34-40.
[15]	Visser AW, de Mutsert R, le Cessie S, den Heijer M, Rosendaal FR, Kloppenburg M, Group NEOS. The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study. Ann Rheum Dis. 2015; 74: 1842-7.
[16]	Giles TD, Berk BC, Black HR, Cohn JN, Kostis JB, Izzo Jr. JL, Weber MA. Expanding the Definition and Classification of Hypertension. The Journal of Clinical Hypertension. 2005; 7: 505-12.
[17]	Onat A, Avci GS, Barlan MM, Uyarel H, Uzunlar B, Sansoy V. Measures of abdominal obesity assessed for visceral adiposity and relation to coronary risk. Int J Obes Relat Metab Disord. 2004; 28: 1018-25.
[18]	Bergman RN. A better index of body adiposity. Obesity (Silver Spring). 2012; 20: 1135.
[19]	Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC, Jr., Spertus JA, Costa F, American Heart A, National Heart L, Blood I. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 2005; 112: 2735-52.
[20]	Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957; 16: 494-502.
[21]	Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.
[22]	Wang H, Bai J, He B, Hu X, Liu D. Osteoarthritis and the risk of cardiovascular disease: a meta-analysis of observational studies. Sci Rep. 2016; 6: 39672.
[23]	Puenpatom RA, Victor TW. Increased prevalence of metabolic syndrome in individuals with osteoarthritis: an analysis of NHANES III data. Postgrad Med. 2009; 121: 9-20.
[24]	Conaghan PG, Vanharanta H, Dieppe PA. Is progressive osteoarthritis an atheromatous vascular disease? Annals of the rheumatic diseases. 2005; 64: 1539-41.
[25]	Louati K, Vidal C, Berenbaum F, Sellam J. Association between diabetes mellitus and osteoarthritis: systematic literature review and meta-analysis. RMD open. 2015; 1: e000077.
[26]	Zhang YM, Wang J, Liu XG. Association between hypertension and risk of knee osteoarthritis: A meta-analysis of observational studies. Medicine (Baltimore). 2017; 96: e7584.
[27]	Yusuf E, Nelissen RG, Ioan-Facsinay A, Stojanovic-Susulic V, DeGroot J, van Osch G, Middeldorp S, Huizinga TW, Kloppenburg M. Association between weight or body mass index and hand osteoarthritis: a systematic review. Annals of the rheumatic diseases. 2010; 69: 761-5.
[28]	Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y, Zhao Y, Wang C. Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine. 2012; 79: 291-7.
[29]	Rahman MM, Kopec JA, Anis AH, Cibere J, Goldsmith CH. Risk of cardiovascular disease in patients with osteoarthritis: a prospective longitudinal study. Arthritis Care Res (Hoboken). 2013; 65: 1951-8.
[30]	Singh G, Miller JD, Lee FH, Pettitt D, Russell MW. Prevalence of cardiovascular disease risk factors among US adults with self-reported osteoarthritis: data from the Third National Health and Nutrition Examination Survey. Am J Manag Care. 2002; 8: S383-91.
[31]	Martin K, Lethbridge-Cejku M, Muller DC, Elahi D, Andres R, Tobin JD, Hochberg MC. Metabolic correlates of obesity and radiographic features of knee osteoarthritis: data from the Baltimore Longitudinal Study of Aging. J Rheumatol. 1997; 24: 702-7.
[32]	Hart DJ, Doyle DV, Spector TD. Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. The Journal of rheumatology. 1995; 22: 1118-23.
[33]	Ong KL, Wu BJ, Cheung BM, Barter PJ, Rye KA. Arthritis: its prevalence, risk factors, and association with cardiovascular diseases in the United States, 1999 to 2008. Ann Epidemiol. 2013; 23: 80-6.
[34]	Sayer AA, Poole J, Cox V, Kuh D, Hardy R, Wadsworth M, et al. Weight from birth to 53 years: a longitudinal study of the influence on clinical hand osteoarthritis. Arthritis Rheum. 2003; 48: 1030-3.
[35]	Aspden RM, Scheven BA, Hutchison JD. Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism. The Lancet. 2001; 357: 1118-20.
[36]	Zhuo Q, Yang W, Chen J, Wang Y. Metabolic syndrome meets osteoarthritis. Nat Rev Rheumatol. 2012; 8: 729-37.
[37]	Wang X, Hunter D, Xu J, Ding C. Metabolic triggered inflammation in osteoarthritis. Osteoarthritis Cartilage. 2015; 23: 22-30.