Anti-cancer Effect of Gold Nanoparticles of Gracilaria sp. against HeLa and MCF-7 Cell Lines

Sugandhi S¹ and Rani G^1,

¹Department of Plant Biology & Plant Biotechnology, S.D.N.B. Vaishnav College for Women, Chennai, India

Cite this paper:
Sugandhi S and Rani G. Anti-cancer Effect of Gold Nanoparticles of Gracilaria sp. against HeLa and MCF-7 Cell Lines. Applied Ecology and Environmental Sciences. 2022; 10(8):534-539. doi: 10.12691/aees-10-8-6

Abstract

The main objective of this study was to examine the anticancer activities of the gold nanoparticles of marine seaweeds viz., Gracilaria verrucosa, G. pudumadamensis and G. salicornia. Gold nanoparticles of the three species of Gracilaria were tested for their anticancer properties in vitro against HeLa and MCF-7 cancer cell lines. HeLa cell line is cervical cancer cells and MCF-7 is breast cancer cells. The anticancer activity of gold nanoparticles of the seaweed was observed based on cell viability and morphology of the treated cells and control. Among the three species, G. verrucosa showed a greater activity with an IC 49.80 against HeLa than the other two species. While greater anticancerous activity was observed in G. salicornia with IC 49.69 against MCF-7 cell line. The morphology of the treated cells showed a great variation when compared to the control cells. Thus, the in vitro assay indicated that the gold nanoparticles synthesized by these red seaweeds are the significant source of a noble anticancer agent. The study also revealed that G. verrucosa, G. pudumadamensis and G. salicornia could be the promising bioagents for cancer therapy in the near future.

Keywords:
gold nanoparticles Gracilaria HeLa MCF-7 cell line MTT

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