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M. Hara, M. Sato, H. Takahashi, S. Takayama, H. Takeyama, Accuracy of monitoring serum carcinoembryonic antigen levels in postoperative stage III colorectal cancer patients is limited to only the first postoperative year, Surg. Today 41 (2011) 1357.

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Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators

1Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo (Boys), Egypt


Journal of Food and Nutrition Research. 2022, Vol. 10 No. 1, 41-49
DOI: 10.12691/jfnr-10-1-6
Copyright © 2022 Science and Education Publishing

Cite this paper:
Hesham Fathy Hassan Hassan, Ahmed Mohamed Mansour, El-Sayed Mohamed El-Sayed. Orlistat and Hydroxycitrate Ameliorate Colon Cancer in Rats: The Impact of Inflammatory Mediators. Journal of Food and Nutrition Research. 2022; 10(1):41-49. doi: 10.12691/jfnr-10-1-6.

Correspondence to: El-Sayed  Mohamed El-Sayed, Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo (Boys), Egypt. Email: elsayed200_1956@yahoo.com

Abstract

Colon cancer (CC) is the third type of cancer worldwide. This study aimed to investigate the possible protective effects of orlistat and hydroxycitrate (HCA) against dimethylhydrazine (DMH) and high-fat diet (HFD)-induced CC in adult male rats. The rats were divided into ten groups including the normal group. The rats were treated with the DMH/HFD, orlistat (32 mg/kg), orlistat/DMH, orlistat/DMH/HFD, HCA (135 mg/kg), HCA/DMH, HCA/DMH/HFD, DMH (40 mg/kg), and HFD (20%) for 16 weeks. Administration of orlistat and HCA improved the measured markers of a colon tumor, inflammatory mediators, oxidative stress, as well as caspase-3 (an apoptotic marker) in the colon tissue compared with the CC group. Furthermore, orlistat and HCA corrected the histopathological lesions in the colon lining. These findings revealed that orlistat and HCA had a positive chemopreventive efficacy and could be viewed as a possible clinical solution for colon cancer.

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