Min Jung Kim¹, Kwang-Hyun Park^{2, 3,}, Hye Jeong Yang^1,, Dai Ja Jang¹, Hak Yong Lee⁴, Young Mi Park⁴, Byeong Soo Kim⁵, Dong Yeop Shin^{4, 5}

Schisandrae chinensis (Omija) is traditionally used as a food-based medicinal/pharmaceutical resources including antidiabetic agent in worldwide. In this study, the optimal combined formula of Omija extract and soybean mixture (OSM) were investigated for its effects on type 2 diabetes model expressed in in Vitro and in Vivo animal model. Using whole extracts, we confirmed inhibitory effects to α-glucosidase, α-amylase and the DPPH scavenging in Vitro and examined glucose tolerance in mice. The combined optimum formulation of OSM were significantly ameliorated type 2 diabetes-related. Furthermore, activation of p-Akt, p-AMPK, p-IRS and GLUT2 expression level is pivotal roles of in this anti-diabetic molecular mechanism on in Vivo without side effects. Therefore, these results suggest that OSM is good resources for improves of type 2 diabetes and its complications.

Schisandrae chinensis, type 2 diabetes, diabetes complication, db/db mice, antioxidant, combined mixture