Article citationsMore >>

Uchida, M., Tsuboi, H., Takahashi, M., Nemoto, A., Seki, K., Tsunoo, H., Martyres, S., Roberts, A., Safety of high doses of Propionibacterium freudenreichii ET-3 culture in healthy adult subjects. Regul Toxicol Pharmacol.60:262-7. July 2011.

has been cited by the following article:

Article

1,4-Dihydroxy-2-naphthoic Acid Sulfate: A Promising Constipation Preventive Agent

1Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan


Journal of Food and Nutrition Research. 2021, Vol. 9 No. 2, 96-101
DOI: 10.12691/jfnr-9-2-6
Copyright © 2021 Science and Education Publishing

Cite this paper:
Hiroshi Kasai, Yuya Kawasaki, Kazuaki Kawai. 1,4-Dihydroxy-2-naphthoic Acid Sulfate: A Promising Constipation Preventive Agent. Journal of Food and Nutrition Research. 2021; 9(2):96-101. doi: 10.12691/jfnr-9-2-6.

Correspondence to: Hiroshi  Kasai, Department of Environmental Oncology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan. Email: h-kasai@med.uoeh-u.ac.jp

Abstract

1,4-Dihydroxy-2-naphthoic acid (DHNA) is a metabolic by-product of fermentation by Propionibacterium and is thought to have a beneficial effect as a prebiotic. As it is unstable in air, we have developed a new stable DHNA derivative, DHNA-4-sulfate (DHNAS), which should be converted to DHNA in vivo. After DHNAS was administered to mice, fecal size enlargement and softening were observed. As a metabolite, DHNA-4-β-glucuronide (DHNAG) was detected in the urine, which suggested the sequential conversion, DHNASàDHNAàDHNAG, in vivo. These 4-OH-blocked DHNA derivatives, DHNAS and DHNAG, were stable at pH 3 and pH 7.4, and in water, while DHNA decomposed rapidly within 20 hrs. DHNAS may be a useful food additive to improve human intestinal health, and a promising constipation preventive agent.

Keywords