Background: Ziziphus spina-christi of family Rhamnaceae is a terrestrial tree often recognized as Christ's thorn jujube. The plant of Ziziphus spina-christi grows in the South and East of Asia as well as in the Middle East zone. Nearly in most of the Arabic countries, Levant, and Saudi Arabia, Ziziphus spina-christi tree is called Sidr mentioned in the Holy Quran. It contains nutritional components that render the plant one of the principal food sources. The plant possesses diverse phytochemical active compounds mostly spinanine A, β sitosterol, rutin, quercetin, betulinic, and kinetic acid. In Saudi Arabia, the Sidr tree has an important therapeutic value as each part of the tree was used to maintain a healthy life. Objective: The present review aimed to collect the different nutritional values, pharmacologic, and biological activities that were linked with the utilization of different parts of Ziziphus spina-christi extracts, which have been reported in the literature. Results: Findings collected from the previously published studies showed that Ziziphus spina-christi extract possesses many pharmacological and biological activities such as hepato, cardio and nephroprotective, antidiabetic, antimicrobial, antiparasitic, anticancer, antiasthma, and antinociceptive activities. Many of these biological activities were attributed to the antioxidant action of Ziziphus spina-christi plant extract. Conclusion: It was experimentally proven that Ziziphus spina-christ extract from the Sidr tree mentioned in the Qur'an has many nutritional values and pharmacological effects that could qualify it to be the subject of other studies in humans until it is used as a supplement or alternative treatment in the future.

Ziziphus spina-christi, Hepatoprotective, Nephroprotective, anticancer, antimicrobial