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Ikeda, I., Kobayashi, M., Hamada, T., Tsuda, K., Goto, H., Imaizumi, K., Nozawa, A., Sugimoto, A. & Kakuda, T., Heat-epimerized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epicatechin gallate, Journal of Agricultural Food Chemistry, 51(25), 7303-7307, 2003.

has been cited by the following article:

Article

Effect of Epimerized Catechins-Rich Green Tea Extract on Global Cognitive Function in Healthy Individuals: A Pilot Study

1Amorepacific R&D Center, Yongin-si, Gyeonggi-do 17074, Korea


Journal of Food and Nutrition Research. 2020, Vol. 8 No. 3, 139-148
DOI: 10.12691/jfnr-8-3-4
Copyright © 2020 Science and Education Publishing

Cite this paper:
Gusang Kwon, A Young Kim, Hyung-Su Kim, Si-Young Cho, Byeongbae Jeon, Wan-Gi Kim, Won-Seok Park. Effect of Epimerized Catechins-Rich Green Tea Extract on Global Cognitive Function in Healthy Individuals: A Pilot Study. Journal of Food and Nutrition Research. 2020; 8(3):139-148. doi: 10.12691/jfnr-8-3-4.

Correspondence to: Won-Seok  Park, Amorepacific R&D Center, Yongin-si, Gyeonggi-do 17074, Korea. Email: wspark@amorepacific.com

Abstract

Green tea consumption has been shown to have many beneficial effects on brain health. A high-temperature-processed green tea extract (HTP_GTE) were developed with high levels of epimerized catechins and its effects were investigated on brain functions. HTP_GTE was found to protects neuronal cells and reduces neurite length against oxidative stress-induced cell damage (p ≤ 0.001). Furthermore, a double-blind, placebo-controlled, randomized clinical study using the Cambridge Neuropsychological Test Automated Battery (CANTAB) showed that daily administration of 500 mg HTP_GTE for 8 weeks significantly improved global cognitive functions in middle-aged healthy subjects (n=23; 40.9 ± 4.4 yrs) (p = 0.049 vs. placebo). These preliminary results suggest that HTP_GTE may have potential as a nutraceutical for cognitive improvement.

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