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Monnier VM. Intervention against the Maillard reaction in vivo. Arch Biochem Biophys 2003; 419: 1-15.

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The Defensive Role of Antioxidants Astaxanthin against Oxidative Damage in Diabetic Rats Injected with Streptozotocin

1College of Food Science and Engineering, Ocean University of China, Qingdao City, Shandong Province, P.R.China

2Food Science and Nutrition Department, College of Agricultural and Marine Sciences, Sultan Qaboos University, Oman


Journal of Food and Nutrition Research. 2017, Vol. 5 No. 3, 191-196
DOI: 10.12691/jfnr-5-3-9
Copyright © 2017 Science and Education Publishing

Cite this paper:
Mohammed Said Moosa Al-Bulish, Changhu Xue, Mostafa I. Waly, Jie Xu, Yuming Wang, Qing-Juan Tang. The Defensive Role of Antioxidants Astaxanthin against Oxidative Damage in Diabetic Rats Injected with Streptozotocin. Journal of Food and Nutrition Research. 2017; 5(3):191-196. doi: 10.12691/jfnr-5-3-9.

Correspondence to: Qing-Juan  Tang, College of Food Science and Engineering, Ocean University of China, Qingdao City, Shandong Province, P.R.China. Email: tangqingjuan@ouc.deu.cn

Abstract

Background: Astaxanthin (ASTA) is a carotenoid which has anti-tumor, anti-diabetic, anti-inflammatory and cardio protective properties and is also a powerful antioxidant. Objective: Consumption of antioxidant-rich foods reduces cellular oxidative stress related health problems. This study aims to assess the antioxidant properties of ASTA, against hydrogen peroxide induced oxidative stress and antioxidant potential properties of ASTA in diabetic rats. Materials and Methods: Streptozotocin (STZ) drug was used as a diabetogenic agent in a single intraperitoneal injection dose of 60 mg/kg body weight of male Sprague-Dawley rats. Diabetic and non-diabetic rats were fed chow diet plus oral feeding contained ASTA. After 12 weeks, following STZ injection, all animals were overnight fasted and then sacrificed; pancreas tissues were homogenized for antioxidant measurements and histopathological examination was done. Results: A significant change in lipid and protein contents of pancreatic tissue was observed, however, this change was reversed after treatment with ASTA. Conclusion: the results of this in-vivo study demonstrated that astaxanthin has a protective effect against STZ-induced hyperglycemia and pancreatic cell injury.

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