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Kumar, M., Nagpal, R., Kumar, R., Hemalatha, R., Verma, V., Kumar, A. Cholesterol-lowering probiotics as potential bio-therapeutics for metabolic diseases. Hindawi Publishing Corporation, experimental diabetes research, 2012.

has been cited by the following article:

Article

The Effects of Probiotic On Serum Lipid Profiles in Patients with type 2 Diabetes Mellitus: A Randomized Clinical Trial

1Department of Nursing, School of Nursing and Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran

2Department of Nutrition & Biochemistry, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran

3School of Nursing and Midwifery, Sabzevar University of Medical Sciences, Sabzevar, Iran

4Department of Public Health, School of Health, Shahid Beheshti University of Medical Sciences, Tehran, Iran


Journal of Food and Nutrition Research. 2016, Vol. 4 No. 12, 795-798
DOI: 10.12691/jfnr-4-12-5
Copyright © 2016 Science and Education Publishing

Cite this paper:
Tahere Tofighiyan, Akram Kooshki, BiBi Leila Hoseini, Maryam Mohammadi. The Effects of Probiotic On Serum Lipid Profiles in Patients with type 2 Diabetes Mellitus: A Randomized Clinical Trial. Journal of Food and Nutrition Research. 2016; 4(12):795-798. doi: 10.12691/jfnr-4-12-5.

Correspondence to: Akram  Kooshki, Department of Nutrition & Biochemistry, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. Email: kooshki.nutr@gmail.com

Abstract

Background & Objectives: With regard to probable mechanisms about probiotics effect in cholesterol lowering and since final conclusion about fat-lowering effect of probiotics is not clear; Present study has been conducted to determine effect of probiotics on serum lipid profile level of patients with type II diabetes mellitus. Material and Methods: This double-blind randomized, clinical trial study was done on 44 type-2 diabetic patients, by available sampling. Patients were allocated to either case or control groups by permuted block randomization. Probiotic group received one probiotic tablet and placebo group received one placebo tablet daily for 8 weeks. At baseline and the end of study, 5 ml blood was collected from each patient after a 14-h fasting in order to measure serum lipid profile. Data were analyzed by descriptive and analytic statistics. Results: Demographic parameters, anthropometric and dietary factors were not significantly different between two groups at baseline and the end of week 8. Probiotic intake caused significant decrease in serum total cholesterol (p=0.0001), LDL (p=0.001) and increase serum HDL (p=0.001) in probiotic group. Results showed that observed difference in LDL and HDL between 2 groups was not significant, but serum cholesterol had a significant difference between 2 groups. Conclusions: This study showed that probiotic supplementation is probably effective in improving risk factors for cardiovascular diseases in type 2 diabetes, via serum lipid profile reduction.

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