Article citationsMore >>

Kumazoe, M., Sugihara, K., Tsukamoto, S., Huang, Y., Tsurudome, Y., Takashi, S., Yumi, S., Naoki, U., Shuya, Y., Kim Y.H., Yamadam K., and Tachibana, H., “67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis” J Clin Invest 132(2), 787-799. 2013.

has been cited by the following article:

Article

Inhibitory Effect of Cancer Cells Proliferation from Epigallocatechin-3-O-gallate

1Department of Korean Food & Culinary Arts, Youngsan University, Busan, Korea


Journal of Food and Nutrition Research. 2015, Vol. 3 No. 4, 281-284
DOI: 10.12691/jfnr-3-4-8
Copyright © 2015 Science and Education Publishing

Cite this paper:
Hyun Woo Kang. Inhibitory Effect of Cancer Cells Proliferation from Epigallocatechin-3-O-gallate. Journal of Food and Nutrition Research. 2015; 3(4):281-284. doi: 10.12691/jfnr-3-4-8.

Correspondence to: Hyun  Woo Kang, Department of Korean Food & Culinary Arts, Youngsan University, Busan, Korea. Email: khw7200@ysu.ac.kr

Abstract

Epigallocatechin-3-O-gallate (EGCG), the major polyphenol of green tea and a functional food ingredient/nutraceutical with health-promoting properties. However, its anti-cancer activities on various cancer cells are still little information. Here, we show that anti-cancer activities of the EGCG were evaluated using apoptosis assays analyzed by flow cytometry. The inhibitory activities of proliferation in MPC-11, Caco-2, and MCF-7 cells, values were 66.2, 60.3, and 74.8% at 10 μM, respectively. In addition, in an flow cytometry assay on the MPC-11, Caco-2, and MCF-7 cells, the EGCG showed a cell apoptosis effect on cancer/tomor in vitro model. Our results indicate that EGCG has anti-cancer activities against human lung cancer cells through inducing cell cycle arrest, DNA damage and activating mitochondrial signal pathway. These results indicate that EGCG effectively inhibits in vitro tumor growth by inducing apoptosis of cancer cells.

Keywords