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Song, K.B., Kim, S.H., Na, J.Y., Park, J.H., Kim, J.K., Kim, J.H., and Kwon, J.K., “Rutin attenuates ethanol-induced neurotoxicity in hippocampal neuronal cells by increasing aldehyde dehydrogenase 2” Food Chem Toxicol 72, 228-233. 2014.

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Article

Rutin Attenuates Lipopolysaccharide-induced Nitric Oxide Production in Macrophage Cells

1Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea

2Department of Food Science & Nutrition, Dong-A University, Busan, Korea

3Department of Pharmacology, Ajou University School of Medicine, Suwon, Korea

4Department of Bioresources and Food Science, Konkuk University, Seoul, Korea


Journal of Food and Nutrition Research. 2015, Vol. 3 No. 3, 202-205
DOI: 10.12691/jfnr-3-3-12
Copyright © 2015 Science and Education Publishing

Cite this paper:
Seung-Jae Lee, Seung Yuan Lee, Hyun Joo Ha, Seon Heui Cha, Si Kyung Lee, Sun Jin Hur. Rutin Attenuates Lipopolysaccharide-induced Nitric Oxide Production in Macrophage Cells. Journal of Food and Nutrition Research. 2015; 3(3):202-205. doi: 10.12691/jfnr-3-3-12.

Correspondence to: Sun  Jin Hur, Department of Animal Science and Technology, Chung-Ang University, Anseong, Korea. Email: hursj@cau.ac.kr

Abstract

Rutin is the major polyphenol found in buckwheat and can downregulate inflammatory responses in macrophages. However, the underlying mechanism is unclear. Overproduction of nitric oxide (NO) by inducible nitric synthase (iNOS) is closely correlated with inflammation and the pathology of a variety of diseases. It has been reported that rutin inhibited various pro-inflammatory mediators, including cytokine signaling in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophage cells, and suppressed the production of NO and the expression of cyclooxygenase-2 (COX-2) and iNOS protein in LPS-stimulated macrophages. These results suggest that rutin exerts anti-inflammatory effects by suppressing the expression of COX-2 and iNOS in RAW 264.7 macrophage cells. Therefore, rutin can be considered as a functional food for the prevention of various diseases.

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