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Gouw SC, van der Bom JG, Ljung R et al. (2013): Factor VIII Products and Inhibitor Development in Severe Hemophilia A. N Engl J Med; 368: 231-9.

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Article

Bleeding Disorders: Insights into Aetiology, Pathogenesis, Diagnosis and Management

1Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia

2Department of Pharmacology, Faculty of Medicine, Tanta University, Tanta, Egypt


International Journal of Hematological Disorders. 2014, Vol. 1 No. 1, 22-26
DOI: 10.12691/ijhd-1-1-4
Copyright © 2014 Science and Education Publishing

Cite this paper:
Ahmed M Kabel. Bleeding Disorders: Insights into Aetiology, Pathogenesis, Diagnosis and Management. International Journal of Hematological Disorders. 2014; 1(1):22-26. doi: 10.12691/ijhd-1-1-4.

Correspondence to: Ahmed  M Kabel, Department of Clinical Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia. Email: drakabel@gmail.com

Abstract

Background: Coagulation plays an important role in haemostasis. Bleeding disorders caused by deficiency of certain coagulation factors such as hemophilia and Von Willebrand disease can affect haemostasis and may endanger life. Aim: To put a focus on the aetiology, pathogenesis, methods of diagnosis and lines of management of bleeding disorders. Conclusion: Bleeding disorders usually result from hereditary deficiency of certain coagulation factors. These disorders often affect lifestyle of the patient and may have serious complications. Further studies are needed to explore the exact pathogenesis of these disorders and new lines of management especially for gene therapy.

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