Article citationsMore >>

Sanacora, G., Zarate, C.A., Krystal, J.H. and Manji, H.K, Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders, Nat Rev Drug Discov, 7. 426-437. 2008.

has been cited by the following article:

Article

Rapid Antidepressant Action of Ketamine in Psychiatric Patients with Suicidality - a Case Series

1Department of Psychiatry, Govt. Medical College & Rajindra Hospital, Patiala, INDIA

2Department of Pharmacology, Guru Gobind Singh Medical College & Hospital (Baba Farid University of Health Sciences), Faridkot, INDIA


American Journal of Medical Sciences and Medicine. 2014, Vol. 2 No. 2, 44-47
DOI: 10.12691/ajmsm-2-2-4
Copyright © 2014 Science and Education Publishing

Cite this paper:
Rajnish Raj, Raj Kumar. Rapid Antidepressant Action of Ketamine in Psychiatric Patients with Suicidality - a Case Series. American Journal of Medical Sciences and Medicine. 2014; 2(2):44-47. doi: 10.12691/ajmsm-2-2-4.

Correspondence to: Rajnish  Raj, Department of Psychiatry, Govt. Medical College & Rajindra Hospital, Patiala, INDIA. Email: drrajnish_raj@yahoo.com

Abstract

Ketamine, a non-competitive NMDA receptor antagonist with rapid antidepressant action, is a novel approach in modulating glutamate receptors for management of treatment-resistant major depressive disorder. It clinically engenders meaningful advances in depression therapeutics. This case series highlights the role of low dose intravenous ketamine infusion i.e., 0.5 mg/kg dissolved in 100 ml normal saline and given over a period of 40 minutes in patients of depression who were contemplating suicide.

Keywords