Soil streptomyces are known as a rich source to produce secondary metabolites. This study was conducted to examine the effect of the Streptomyces sp. extracts against the uro-pathogen isolates from urinary tract infections in pregnancy from Kassala state. Cultural, morphological and physiological characterization of 15 microorganisms isolates from four soil samples indicated that all isolates belonged to the Streptomyces genus. All Streptomyces isolates produced chitinase enzyme except isolate SU11. After 72 hours all of the isolates were produced L-asparaginase enzyme. Ethyl acetate extracts of Antimicrobial were used for secondary screening against uro-pathogen. The high activity has been observed against Gram-positive bacteria with a percentage of 73.3% when compared to gram-negative bacteria. Whilst 26.7% has a high activity against Gram-negative comparing with Gram-positive bacteria, and different activity was shown against candida spp.

Streptomyces, Chitinase, L-asparaginase, Antimicrobial, Uro-pathogen