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Diaz – Cruz ES, Furth PA (2010) Deregulated estrogen receptor α and p53 heterozygosity collaborate in the development of mammary hyperplasia: Cancer Res 62: 61-76.

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Article

Effect of Anti-Thyroperoxidase on Thyroid Gland and Breast Tissue: A Comprehensive Review

1Department of Bio-chemistry, Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, India

2Department of Bio-chemistry, Vaidehi Institute of Medical Sciences, and Research Centre, Bangalore, India

3Department of Bio-chemistry, Kasturba Medical College, Manipal Universiy, Manipal, India

4Department of Microbiology, Prathima Institute of Medical Sciences, Karimnagar, India


American Journal of Medicine Studies. 2014, Vol. 2 No. 2, 34-37
DOI: 10.12691/ajms-2-2-2
Copyright © 2014 Science and Education Publishing

Cite this paper:
Sabitha Kandi, Venkata Bharatkumar Pinnelli, Pragna Rao, K V Ramana. Effect of Anti-Thyroperoxidase on Thyroid Gland and Breast Tissue: A Comprehensive Review. American Journal of Medicine Studies. 2014; 2(2):34-37. doi: 10.12691/ajms-2-2-2.

Correspondence to: Sabitha  Kandi, Department of Bio-chemistry, Chalmeda Anandarao Institute of Medical Sciences, Karimnagar, India. Email: tejaswani19@gmail.com

Abstract

Relationship between thyroid disease and breast tissue has long been debated as both the tissues have same embryological origin. Recent studies have implicated the possible role of thyroid dysfunction in the development and progression of breast related disorders. In view of increased prevalence of hypo and hyper thyroidism globally, there is a possibility of hormonal imbalance which may contribute to the initiation of tumor growth. Current literature has confirmed the role of sodium-iodide symporter (NIS) gene expression in breast cancers. Elevated anti-thyroperoxidase enzyme has been associated with increased risk of breast cancer. Activity of thyroid gland in post menopausal women, role of iodide levels and its relation to breast tissue and development of breast cancer needs extensive evaluation. In this comprehensive review we describe the role of NIS in thyroid gland functioning, thyroid hormone signaling mechanism.

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