American Journal of Medicine Studies. 2014, 2(2), 31-33DOI:
Abstract: Mannitol, a novel osmotic agent and natural polyol extensively, is sometimes effective in reversing acute renal injury, but it can also induce the acute renal tubular injury. The role of mannitol in kidney is controversial. It is a small particle, distributed only in the extracellular space, is freely filtered at the glomerulus, and is not reabsorbed by the tubules. This systematic review was conducted to sum up the association of mannitol with renal diseases. The mannitol may precipitate acute renal failure if serum osmolarity exceeds 320 mOsm/L, but the lower concentration might be positive. However, more studies should be performed in the future.