Article citationsMore >>

den Besten, G.; Lange, K.; Havinga, R.; van Dijk, T.H.; Gerding, A.; van Eunen, K.; Müller, M.; Groen, A.K.; Hooiveld, G.J.; Bakker, B.M.; Reijngoud, D.J. Gut-Derived Short-Chain Fatty Acids Are Vividly Assimilated into Host Carbohydrates and Lipids. Am. J. Physiol. Gastrointest. Liver Physiol. 2013, 305, G900–G910.

has been cited by the following article:

Article

Anti-NAFLD Effect of SCFAs-rich Fermented Lemon by- product in Mice fed a High-Fat Diet

1R&D Center, Bio-Ray Biotech, INC, No. 21-3, Shennong E. Rd., Changzhi, Pingtung, Taiwan

2Agricultural Technology Research Institute, No.52, Kedong 2nd Rd., Zhunan Township, Miaoli County, Taiwan

3Kao-Ho Hospital, No. 460, Bo'ai 1st Rd., Gushan Dist, Kaohsiung City, Taiwan


Journal of Food and Nutrition Research. 2026, Vol. 14 No. 2, 45-53
DOI: 10.12691/jfnr-14-2-1
Copyright © 2026 Science and Education Publishing

Cite this paper:
Ho-Shin Huang, Chi-Yu Yang, Pei-Chun Lin, Chun-Mei Lu, Ting-Yuan Hsu. Anti-NAFLD Effect of SCFAs-rich Fermented Lemon by- product in Mice fed a High-Fat Diet. Journal of Food and Nutrition Research. 2026; 14(2):45-53. doi: 10.12691/jfnr-14-2-1.

Correspondence to: Ho-Shin  Huang, R&D Center, Bio-Ray Biotech, INC, No. 21-3, Shennong E. Rd., Changzhi, Pingtung, Taiwan. Email: adinol.huang@gmail.com

Abstract

This study investigated the therapeutic potential of fermented lemon peel (FLP07) in mitigating HFD-induced NAFLD, utilizing a mouse model to compare its efficacy against the hepatoprotective agent silymarin. While HFD-fed mice exhibited significant weight gain, dyslipidemia, and intervention with FLP07 effectively improved serum triglyceride (TG) and total cholesterol (TC) levels. Furthermore, FLP07 partially restored the AST/ALT ratio and significantly reduced hepatic lipid droplet accumulation, showing comparable efficacy to silymarin. These results suggest that FLP07 is a promising natural dietary supplement for managing NAFLD and dyslipidemia.

Keywords