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Razola-Díaz, M.D.C.; De Montijo-Prieto, S.; Guerra-Hernández, E.J.; Jiménez-Valera, M.; Ruiz-Bravo, A.; Gómez-Caravaca, A.M.; Verardo, V. Fermentation of Orange Peels by Lactic Acid Bacteria: Impact on Phenolic Composition and Antioxidant Activity. Foods 2024, 13, 1212.

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Article

Anti-NAFLD Effect of SCFAs-rich Fermented Lemon by- product in Mice fed a High-Fat Diet

1R&D Center, Bio-Ray Biotech, INC, No. 21-3, Shennong E. Rd., Changzhi, Pingtung, Taiwan

2Agricultural Technology Research Institute, No.52, Kedong 2nd Rd., Zhunan Township, Miaoli County, Taiwan

3Kao-Ho Hospital, No. 460, Bo'ai 1st Rd., Gushan Dist, Kaohsiung City, Taiwan


Journal of Food and Nutrition Research. 2026, Vol. 14 No. 2, 45-53
DOI: 10.12691/jfnr-14-2-1
Copyright © 2026 Science and Education Publishing

Cite this paper:
Ho-Shin Huang, Chi-Yu Yang, Pei-Chun Lin, Chun-Mei Lu, Ting-Yuan Hsu. Anti-NAFLD Effect of SCFAs-rich Fermented Lemon by- product in Mice fed a High-Fat Diet. Journal of Food and Nutrition Research. 2026; 14(2):45-53. doi: 10.12691/jfnr-14-2-1.

Correspondence to: Ho-Shin  Huang, R&D Center, Bio-Ray Biotech, INC, No. 21-3, Shennong E. Rd., Changzhi, Pingtung, Taiwan. Email: adinol.huang@gmail.com

Abstract

This study investigated the therapeutic potential of fermented lemon peel (FLP07) in mitigating HFD-induced NAFLD, utilizing a mouse model to compare its efficacy against the hepatoprotective agent silymarin. While HFD-fed mice exhibited significant weight gain, dyslipidemia, and intervention with FLP07 effectively improved serum triglyceride (TG) and total cholesterol (TC) levels. Furthermore, FLP07 partially restored the AST/ALT ratio and significantly reduced hepatic lipid droplet accumulation, showing comparable efficacy to silymarin. These results suggest that FLP07 is a promising natural dietary supplement for managing NAFLD and dyslipidemia.

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