Putri Novitasari^{1, 2}, Rimbawan Rimbawan^1,, Hardinsyah Hardinsyah¹, Hadi Riyadi¹

“Variations in the FTO gene and specific dietary interventions have been linked to inflammatory and hormonal biomarker changes in obese individuals. This research focused on assessing the impact of a 28-day balanced diet intervention on inflammation markers associated with cardiovascular risk among different FTO rs9939609 gene single nucleotide polymorphisms (SNPs) in obese women. This randomized controlled trial involved 38 women aged 18–25 with high body fat, who were randomly categorized into four groups based on FTO rs9939609 SNP and balanced diet intervention for 28 days: Allele A carriers + diet (DAC, n=12), TT genotype + diet (DTH, n=8), Allele A carriers without diet (CAC, n=10), and TT genotype without diet (CTH, n=8). Participants underwent nutritional education and had interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP), and adiponectin (ADP) measured pre- and post-intervention. The students' t-test statistical analyses were conducted using SPSS software. Initial IL-6 levels were highest in CAC (99.6 ± 29.4 ng/L) and lowest in DAC (76.4 ± 22.4 ng/L). Hs-CRP was highest in CTH (26.6 ± 9.48 ng/mL) and lowest in DTH (21.6 ± 6.0 ng/mL). ADP was highest in CTH (0.54 ± 0.08 ng/mL) and lowest in DAC (0.48 ± 0.10 ng/mL). After 28 days of balanced diet, none of the inflammatory markers showed statistically significant changes in all groups (P≥0.05). The balanced diet intervention did not significantly affect inflammatory markers linked to cardiovascular risk among all variants. Future studies should explore the prolonged effects of specific dietary components on inflammation and cardiovascular outcomes across diverse populations or other genes.”.

FTO rs9939609, inflammation, cardiovascular risk, obese women