Raquel da Silva Vieira^1,, Eduardo José de Arruda², Antônio Pancrácio de Souza³, Danilo Tófoli⁴, Rosângela Assis Jacques⁵, Patrick da Silva Mirowski³, Ana Cristina Jacobowski¹, Maria Lígia Rodrigues Macedo¹, Valter Aragão do Nascimento¹, Rita de Cássia Avellaneda Guimarães¹, Paulo Roberto Haidamus de Oliveira Bastos¹, Danielle Bogo¹

There is a need to find sustainable alternatives to control this arbovirus vector due the increasing resistance of Aedes aegypti to conventional chemical insecticides especially in tropical and subtropical countries. This study aims to evaluate the larvicidal potential of the Caryocar brasiliense fruit pulp as an eco-friendly alternative to the control of Aedes aegypti. Using mosquito third instar larvae, in vitro and in vivo toxicity tests were performed with the fruit pulp of Caryocar brasiliense. Larvicidal activity was observed at all concentrations tested, with no evidence of toxicity in vitro and in vivo, indicating safety for non-target organisms. The results suggest that the fatty esters present in the pulp of Caryocar brasiliense may be a promising alternative for the control of Aedes aegypti. These findings pave the way for further studies on the structure-activity relationship of natural molecules in combating mosquito-borne diseases.

Caryocar brasiliense, fatty acids, larvicidal activity, bioactive molecules, eco-friendly