Background and aim: Our aim was to evaluate the relationship between magnesium and HbA1c levels and the development of polyneuropathy (PNP) in patients with type 2 diabetes and to determine the cut-off values of magnesium (Mg) and HbA1c that may cause PNP. Methods: For all 270 patients with type 2 diabetes mellitus were performed electroneurographical examinations according to the polyneuropathy protocol, serum magnesium and HbA1c levels were measured and recorded. Results: The mean age was higher in the group with PNP. The distribution of sex ratios among the PNP groups was statistically different, with more males in the PNP group (P=0.016). Mg values were statistically lower in patients with PNP (P<0.001). HbA1c values were statistically higher in patients with PNP (P=0.013). Patients with Mg values less than or equal to 1.95mg/dl were 11.3 times and patients with HbA1c values greater than or equal to 8.95mmol/mol were 3.9 times more likely to develop PNP. Conclusions: Although the lower normal limit for Magnesium was 1.6mg/dl and the upper limit for HbA1c was 6.3mmol/mol according to our laboratory standards, we found a more real cut-off value in terms of predisposing to the development of polyneuropathy in our patients.

hypomagnesemia, HbA1c, type 2 diabetes mellitus, cut-off, polyneuropathy