Karnon Coulibaly¹, Fatoumata Camara¹, Ekoua Regina Krabi², Wahauwouele Hermann Coulibaly^3,, Brahima Kande⁴, Koffi Cyrille Tan¹

In Africa, and particularly in Ivory Coast, metabolic diseases represent a public health problem. Face at this problem the prevention seems to be a suitable solution. The objective of this work was to evaluate the anti-diabetic properties and nutritional effects of different formulations made from soumbara and Moringa oleifera leaves through an animal experiment. For this purpose, ten batches of five mouse were constituted. The animals of nine batches were made diabetic by alloxane. Mouse in lot 3 were given daily doses of glibenclamide at 5 mg/Kg bw and lots 4, 5, 6 ,7,8, 9 and 10 were given the aqueous extract of the formulations at 5000 mg/Kg bw for 21 days. The blood glucose levels of the mouse were measured. At the end of the experiment, the mouses were fasted and anaesthetized with chloral and then sacrificed. Their blood was collected in dry tubes to determine their biochemical parameters. Thus, the results showed that the mouse which received by gavage the aqueous extracts of the diets particularly the formulation S20M80 and S30M70, proved to be more effective in the treatment of hyperglycemia. The observed results showed overall, an increase in body weight (2.33 to 14.33 g), serum iron level (78.25 to 96.41 μg /mL), but also a decrease in blood glucose level (1.70 to 1.16 g/l). Based on these results, the S20M80 formulation seemed to be suitable to help prevent type 2 diabetes and reduce micronutrient deficiencies.

Moringa leaves, soumbara, food formulation, biochemical parameters