Laode Muslimin^1,, Ramdan Panigoro², Gaga Irawan Nugraha², Susi Susanah³, Gemilang Lara Utama⁴, Mas Rizki A.Asyamsumarno⁵, Tasnim ⁶

Anemia is one of the current health problems, about 50% of anemia is caused by dengue fever so this situation has become a global problem that harms human health, and the social and economic development of the country. The purpose of this review is to examine the implications of drying and fermentation processing methods, anti-nutrients and iron bioavailability of Moringa leaves on parameters of iron deficiency anemia. The narrative method describes research results based on inclusion criteria through article searches in the Google Scholar, PubMed, and Garuda databases. 54 articles corroborate the claims of the effectiveness of Moringa leaves in the treatment of iron deficiency anemia. consists of 34 preclinical research articles using mouse models. Moringa leaf supplementation as an anti-anemia in iron deficiency anemia rat model can be in the form of extract or dry powder and obtained from different processing methods. Moringa leaves are processed into a dry extract and/or dry powder capable of ameliorating hematological and biochemical parameters in preclinical research. The processing method has an impact on changes in anti-nutritional and iron bioavailability of Moringa leaves which have a positive impact on indicators of iron deficiency anemia.

anemia, Moringa oleifera, processing, anti-nutrition, iron bioavailability, hematology, biochemistry