Venkataramanaiah Poli¹, Yenukolu Aparna¹, Srinivasulu Reddy Motireddy^2,

The main purpose of this study is to review the 6-gingerol effect in antidiabetic in mammalian system. Among them 6-gingerol have the potential to prevent the development of diabetes complications. This study was reviewed in mammalian systems by giving 6-gingerol orally with a specific defined dose to diabetes rats. 6-gingerol generally activates the Adenosine Monophosphate-Activated Protein Kinase (AMPK) path, which is the main target for the development of anti-diabetes drugs. These results indicate a significant antidiabetic potential of 6-gingerol. Treatment of doses depends on 6-gingerol at concentration varies indicating potential mechanisms in improving the effects of diabetes, both in in vitro and in vivo models with AMPK activation. Data relevant to the 6-gingerol role in diabetes is limited. Although some clinical trials have proven that 6-gingerol have efficiency in diabetes complications, the exact mechanism of AMPK activation by 6-gingerol must be further investigated. In this review, most of the focused on 6-gingerol are known to activate AMPK by increasing intracellular calcium levels, further studies are needed to determine the exact role of gingerol in the activation of the Ca²⁺/calmodulin-dependent protein kinase kinase (CAMKK)-AMPK pathway. Although ginger is considered safe in some cases, it might cause nausea, vomiting, gastric irritability, excessive bleeding in pregnant women and death in some rats. Therefore, clinical trials must be carried out further to estimate acute and chronic toxicity to assess the safety of ginger and related bioactive compounds.

6-gingerol, ginger, AMPK, anti-diabetic, toxicity