Jihee Lee1,
Inae Jeong1,
Gwang-Woo Kim1,
Taesang Son1,
Yujeong Kim1,
Woojin Jun1, 2,
Jeongjin Park1, 2,
Ok-Kyung Kim1, 2,
1Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Korea
2Human Ecology Research Institute, Chonnam National University, Gwangju 61186, Korea
Journal of Food and Nutrition Research.
2021,
Vol. 9 No. 12, 614-625
DOI: 10.12691/jfnr-9-12-1
Copyright © 2021 Science and Education PublishingCite this paper: Jihee Lee, Inae Jeong, Gwang-Woo Kim, Taesang Son, Yujeong Kim, Woojin Jun, Jeongjin Park, Ok-Kyung Kim. Standardized Ethanolic Extracts of
Boswellia serrata Ameliorate Symptoms of Osteoarthritis by Direct Effects on Chondrocytes.
Journal of Food and Nutrition Research. 2021; 9(12):614-625. doi: 10.12691/jfnr-9-12-1.
Correspondence to: Ok-Kyung Kim, Division of Food and Nutrition, Chonnam National University, Gwangju 61186, Korea. Email:
20woskxm@jnu.ac.krAbstract
We investigated whether standardized ethanolic extracts of Boswellia (FJH-BS) could alleviate the symptoms of osteoarthritis, including pain, inflammation, and degradation of articular cartilage. Sprague-Dawley rats with monosodium iodoacetate (MIA)-induced osteoarthritis received supplementation of FJH-BS at 80 and 125 mg/kg body weight. We found that FJH-BS supplementation reduced histological and architectural changes and pain levels in rats with MIA-induced osteoarthritis. In addition, FJH-BS supplementation suppressed mRNA expression of matrix metalloproteinases (MMPs) and pro-inflammatory mediators, including cyclooxygenase-2, prostaglandin E2, and pro-inflammatory cytokines. Furthermore, FJH-BS treatment directly suppressed cell death, inflammation, and expression of MMPs in H2O2- or LPS-treated primary chondrocytes. Our results suggest that supplementation with standardized FJH-BS may prevent osteoarthritis progression by directly influencing chondrocytes.
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