Dayan Li^1,, Yue Liu², Miguo Ma³, Fuli Li¹, Miaodan Pan¹, Lili Zhao¹

Background: Cardiovascular disease is the very common disease characterized. It may cause unpleasant symptoms as well as increases the person's risk of disability. With an ageing population, increasing rates of cardiovascular disease and limited access to specialists, new methods of care, like nurse practitioners need to be assessed to meet patient specific needs and provide sustainable care. We performed a meta-analysis to evaluate the effect of nurse practitioner-led care on the outcomes of care for adult subjects with cardiovascular disease. Methods: A systematic literature search up to October 2021 (between 2000 and 2021) was done and 8 studies included 4019 subjects with cardiovascular disease at the start of the study; 2064 of them were provided with nurse practitioner-led care and 1955 were standard care. They were reporting relationships about the effect of nurse practitioner-led care on the outcomes of care for adult subjects with cardiovascular disease. We calculated the odds ratio (OR) and mean difference (MD) with 95% confidence intervals (CIs) to assess the effect of nurse practitioner-led care on the outcomes of care for adult subjects with cardiovascular disease using the dichotomous and continuous methods with a random or fixed-effect model. Results: Nurse practitioner-led care had significantly lower 30-day readmission for cardiovascular disease (OR, 0.63; 95% CI, 0.47-0.86, p=0.004) compared to standard care in subjects with cardiovascular disease. However, nurse practitioner-led care had no significant difference in length of stay after cardiac surgery (MD, -1.27; 95% CI, -3.72-1.19, p=0.31), health-related quality of life: SF-36 physical composite score (MD, 0.21; 95% CI, -0.75-1.17, p=0.67), and health-related quality of life: SF-36 mental composite score (MD, -0.79; 95% CI, -2.65 -1.08, p=0.41) compared to standard care in subjects with cardiovascular disease. Conclusions: Nurse practitioner-led care had significantly lower 30-day readmission for cardiovascular disease; however, nurse practitioner-led care had no significant difference in length of stay after cardiac surgery, and health-related quality of life: SF-36 physical composite score, and SF-36 mental composite score compared to standard care in subjects with cardiovascular disease. Further studies are required to validate these findings.

cardiovascular disease, nurse practitioner-led care, 30-day readmission for cardiovascular disease; length of stay after cardiac surgery, health-related quality of life: SF-36 physical composite score, and health-related quality of life: SF-36 mental composite score