Sang Jae Kwak¹, Hyun Woo Kang^1,

The free radical scavenging activity of extracts prepared from Myelophycus simplex was evaluated by using an ESR spectrometer. For this study, Myelophycus simplex was 70% ethanol extraction was performed. Myelophycus simplex extracts scavenged DPPH, hydroxyl, superoxide, and alkyl radicals. Especially, the extracts exhibited the highest scavenging activity on hydroxyl radical, which is deemed of the strongest radical. In addition, we also evaluated the protective effects of Myelophycus simplex extract on 3.5% alcohol-induced damage (oxidative stress) in normal liver cells. The Myelophycus simplex extract inhibited productions of reactive oxygen species (ROS), and cell death against alcohol-induced liver cell damage. It was presumed that the Myelophycus simplex extract was involved in regulation of apoptosis-related pathway in the cell environments. These results indicate that Myelophycus simplex extract possess antioxidative activity on liver cells.

Myelophycus simplex, antioxidant, free radical, liver cells, flow cytometer