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Meyer AG, Easton CJ, Lincoln SF, Simpson GW. β-Cyclodextrin as a Scaffold for Supramolecular Chemistry, To Reverse the Regioselectivity of Nitrile Oxide Cycloadditions. The Journal of Organic Chemistry, 63(24), 9069-9075, 1998.

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Article

An Undergraduate Experiment Using Cyclodextrin – Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples

1Chemistry Department, College of Science, United Arab Emirates University, P.O. Box 15551 Al-Ain, UAE

2Civil and Environmental Engineering Department, United Arab Emirates University, P.O. Box 15551 Al-Ain, UAE


World Journal of Chemical Education. 2019, Vol. 7 No. 4, 242-247
DOI: 10.12691/wjce-7-4-2
Copyright © 2019 Science and Education Publishing

Cite this paper:
Mohammed A. Meetani, Ahmad Alhalabi, Mohammed K. Al-tabaji, Noor I Albadawi, Nada Elmari, Soleiman Hisaindee, Abdullah Al-Hemyari, Munjed Maraqa. An Undergraduate Experiment Using Cyclodextrin – Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples. World Journal of Chemical Education. 2019; 7(4):242-247. doi: 10.12691/wjce-7-4-2.

Correspondence to: Mohammed  A. Meetani, Chemistry Department, College of Science, United Arab Emirates University, P.O. Box 15551 Al-Ain, UAE. Email: mmeetani@uaeu.ac.ae

Abstract

The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, 1H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase.

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