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do Amaral LH, do Carmo FA, Amaro MI, de Sousa VP, da Silva L, de Almeida GS, et al. Development and Characterization of Dapsone Cocrystal Prepared by Scalable Production Methods. AAPS PharmSciTech. , 19(6), 2687-2699, 2018.

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Article

An Undergraduate Experiment Using Cyclodextrin – Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples

1Chemistry Department, College of Science, United Arab Emirates University, P.O. Box 15551 Al-Ain, UAE

2Civil and Environmental Engineering Department, United Arab Emirates University, P.O. Box 15551 Al-Ain, UAE


World Journal of Chemical Education. 2019, Vol. 7 No. 4, 242-247
DOI: 10.12691/wjce-7-4-2
Copyright © 2019 Science and Education Publishing

Cite this paper:
Mohammed A. Meetani, Ahmad Alhalabi, Mohammed K. Al-tabaji, Noor I Albadawi, Nada Elmari, Soleiman Hisaindee, Abdullah Al-Hemyari, Munjed Maraqa. An Undergraduate Experiment Using Cyclodextrin – Assisted Sensitive Fluorescence Detection and Quantitation of Dapsone Drug in Wastewater Samples. World Journal of Chemical Education. 2019; 7(4):242-247. doi: 10.12691/wjce-7-4-2.

Correspondence to: Mohammed  A. Meetani, Chemistry Department, College of Science, United Arab Emirates University, P.O. Box 15551 Al-Ain, UAE. Email: mmeetani@uaeu.ac.ae

Abstract

The guest-host interaction between Dapsone drug and β-cyclodextrin (β-CD) was investigated using fluorescence spectroscopy, 1H-NMR, and liquid chromatography with fluorescence detection. The optimized conditions for the interaction were investigated by spectrofluorometry and were found to be at 0.2 mg/mL (0.176 mM) of β-CD and pH 8.8. For these conditions, very low concentration of Dapsone drug of 2.4 ng/mL (12.97 nM) can be detected. The standard addition method was utilized to detect Dapsone in influent and effluent wastewater samples in the sub parts per billion concentration range by HPLC-FLD using β-CD as an additive in the mobile phase.

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