1Department of Chemistry and Biochemistry, Hampton University, Hampton, VA 23668, U.S.A.
World Journal of Chemical Education.
2019,
Vol. 7 No. 3, 216-224
DOI: 10.12691/wjce-7-3-5
Copyright © 2019 Science and Education PublishingCite this paper: Michelle K. Waddell, Charles M. Bump, Edmund M. Ndip, Godson C. Nwokogu. Determination of the
p/
o-Isomer Product Ratios in Electrophilic Aromatic Nitration of Alkylbenzenes Using High Resolution
1H NMR Spectroscopy.
World Journal of Chemical Education. 2019; 7(3):216-224. doi: 10.12691/wjce-7-3-5.
Correspondence to: Godson C. Nwokogu, Department of Chemistry and Biochemistry, Hampton University, Hampton, VA 23668, U.S.A.. Email:
godson.nwokogu@hamptonu.eduAbstract
High resolution 1H NMR spectroscopy, an increasingly available instrumental method, is used in undergraduate organic laboratory practice as a simpler alternative to gas chromatographic method for the direct determination of the p/o ratios of the crude reaction product from the nitration of alkylbenzenes. The choice of isopropylbenzene as a substrate illustrates that steric effect can be significant in controlling regioselectivity in electrophilic aromatic substitution reactions.
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